Adolescent idiopathic scoliosis: evidence for intrinsic factors driving aetiology and progression

Matthew M. P. Newton Ede, Simon W. Jones

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18 Citations (Scopus)
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Adolescent idiopathic scoliosis (AIS) is now considered to be a multifactorial heterogeneous disease, with recent genomic studies supporting the role of intrinsic factors in contributing to the onset of disease pathology and curve progression. Understanding the key molecular signalling pathways by which these intrinsic factors mediate AIS pathology may facilitate the development of pharmacological therapeutics and the identification of predictive markers of progression. The heterogenic nature of AIS has implicated multiple tissue types in the disease pathophysiology, including spinal bone, intervertebral disc and paraspinal muscles. In this review, we highlight some of the mechanisms and intrinsic molecular regulators within these different tissue types and review the evidence for their involvement in AIS pathology.
Original languageEnglish
Pages (from-to)2075–2080
JournalInternational Orthopaedics
Issue number10
Early online date10 Mar 2016
Publication statusPublished - Oct 2016


  • Adolescent idiopathic scolisosis
  • Epigenetics
  • Bone
  • Intervertebral disc
  • Paraspinal muscles


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