Absorption and scattering imaging of tissue with steady-state second-differential spectral-analysis tomography

Heng Xu; Brian W. Pogue; Hamid Dehghani; Keith D. Paulsen; Roger Springett; Jeff F. Dunn

doi:10.1364/OL.29.002043

Absorption and scattering imaging of tissue with steady-state second-differential spectral-analysis tomography

Heng Xu^*, Brian W. Pogue, Hamid Dehghani, Keith D. Paulsen, Roger Springett, Jeff F. Dunn

^*Corresponding author for this work

Computer Science

Research output: Contribution to journal › Article › peer-review

Abstract

A novel approach to reconstructing both the absorption and the scattering properties of a turbid medium simultaneously from steady-state broadband spectral measurements is presented that utilizes second-differential fitting to the water spectrum to estimate the optical path length in tissue. Theoretical and experimental evidence is provided to demonstrate the robust accuracy of the spectroscopy approach and reconstructed absorption images. The steady-state broadband CCD system has the potential to provide accurate chromophore imaging without the technological complexity of time- or frequency-domain systems.

Original language	English
Pages (from-to)	2043-2045
Number of pages	3
Journal	Optics Letters
Volume	29
Issue number	17
DOIs	https://doi.org/10.1364/OL.29.002043
Publication status	Published - 1 Sept 2004

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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abstract = "A novel approach to reconstructing both the absorption and the scattering properties of a turbid medium simultaneously from steady-state broadband spectral measurements is presented that utilizes second-differential fitting to the water spectrum to estimate the optical path length in tissue. Theoretical and experimental evidence is provided to demonstrate the robust accuracy of the spectroscopy approach and reconstructed absorption images. The steady-state broadband CCD system has the potential to provide accurate chromophore imaging without the technological complexity of time- or frequency-domain systems.",

author = "Heng Xu and Pogue, {Brian W.} and Hamid Dehghani and Paulsen, {Keith D.} and Roger Springett and Dunn, {Jeff F.}",

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AU - Xu, Heng

AU - Pogue, Brian W.

AU - Dehghani, Hamid

AU - Paulsen, Keith D.

AU - Springett, Roger

AU - Dunn, Jeff F.

PY - 2004/9/1

Y1 - 2004/9/1

N2 - A novel approach to reconstructing both the absorption and the scattering properties of a turbid medium simultaneously from steady-state broadband spectral measurements is presented that utilizes second-differential fitting to the water spectrum to estimate the optical path length in tissue. Theoretical and experimental evidence is provided to demonstrate the robust accuracy of the spectroscopy approach and reconstructed absorption images. The steady-state broadband CCD system has the potential to provide accurate chromophore imaging without the technological complexity of time- or frequency-domain systems.

AB - A novel approach to reconstructing both the absorption and the scattering properties of a turbid medium simultaneously from steady-state broadband spectral measurements is presented that utilizes second-differential fitting to the water spectrum to estimate the optical path length in tissue. Theoretical and experimental evidence is provided to demonstrate the robust accuracy of the spectroscopy approach and reconstructed absorption images. The steady-state broadband CCD system has the potential to provide accurate chromophore imaging without the technological complexity of time- or frequency-domain systems.

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U2 - 10.1364/OL.29.002043

DO - 10.1364/OL.29.002043

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EP - 2045

JO - Optics Letters

JF - Optics Letters

IS - 17

ER -

Absorption and scattering imaging of tissue with steady-state second-differential spectral-analysis tomography

Abstract

ASJC Scopus subject areas

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