Targeting New Mechanisms In The Control Of Thymus Function To Restore Balanced T-cell Production

Research output

Research output per year 2021 2023 2024

• 7 Article
• 1 Review article
• 1 Preprint

Research output per year

Research output per year

Search results

• 2024

  Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

  Ohigashi, I., White, A. J., Yang, M-T., Fujimori, S., Tanaka, Y., Jacques, A., Kiyonari, H., Matsushita, Y., Turan, S., Kelly, M. C., Anderson, G. & Takahama, Y., 11 Mar 2024, In: eLife. 12, 24 p., 92552.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Developmental 100%
  • Autoantigens 91%
  • Thymocytes 89%
  • Thymus Gland 79%
  • Epithelium 63%
• 2023

  Assembling the thymus medulla: Development and function of epithelial cell heterogeneity

  James, K. D., Cosway, E. J., Parnell, S. M., White, A. J., Jenkinson, W. E. & Anderson, G., 31 Dec 2023, (E-pub ahead of print) In: BioEssays. 11 p., 2300165.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Thymus Gland 100%
  • Heterogeneity 95%
  • Epithelial Cells 74%
  • T-Lymphocytes 64%
  • Central Tolerance 39%
  1 Downloads (Pure)

• Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

  Ohigashi, I., White, A. J., Yang, M-T., Fujimori, S., Tanaka, Y., Jacques, A., Kiyonari, H., Matsushita, Y., Turan, S., Kelly, M. C., Anderson, G. & Takahama, Y., 4 Oct 2023, bioRxiv.

  Research output: Working paper/Preprint › Preprint

  • Autoantigens 100%
  • Thymocytes 97%
  • Thymus Gland 87%
  • Epithelium 69%
  • Epithelial Cells 64%

• Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk

  White, A. J., Parnell, S. M., Handel, A., Maio, S., Bacon, A., Cosway, E. J., Lucas, B., James, K. D., Cowan, J. E., Jenkinson, W. E., Hollander, G. A. & Anderson, G., 1 Jan 2023, In: Journal of Immunology. 210, 1, p. 40-49 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thymocytes 100%
  • Epithelial Cells 66%
  • Genes 37%
  • T-Lymphocytes 7%
  • RNA Sequence Analysis 6%
  29 Downloads (Pure)

• Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla

  Lucas, B., White, A. J., Klein, F., Veiga-Villauriz, C., Handel, A., Bacon, A., Cosway, E. J., James, K. D., Parnell, S. M., Ohigashi, I., Takahama, Y., Jenkinson, W. E., Hollander, G. A., Lu, W-Y. & Anderson, G., 12 Apr 2023, In: Nature Communications. 14, 1, 14 p., 2066.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • progeny 100%
  • set theory 74%
  • Thymus Gland 70%
  • Epithelial Cells 51%
  • regulators 46%
  20 Downloads (Pure)

• The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration

  Cosway, E. J., James, K. D., White, A. J., Parnell, S. M., Bacon, A., McKenzie, A. N. J., Jenkinson, W. E. & Anderson, G., 8 Nov 2023, In: Nature Communications. 14, 1, 11 p., 7201.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alarmins 100%
  • Interleukin-33 90%
  • regeneration 74%
  • Thymus Gland 63%
  • eosinophils 60%
  26 Downloads (Pure)

• The medulla controls effector primed γδT-cell development in the adult mouse thymus

  James, K. D., White, A. J., Jenkinson, W. E. & Anderson, G., 6 Jun 2023, In: European Journal of Immunology. 53, 6, e2350388.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thymus Gland 100%
  • T-Lymphocytes 64%
  • T-Lymphoid Precursor Cells 16%
  • Chemotactic Factors 12%
  • Immunity 9%
  10 Downloads (Pure)
• 2022

  Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration

  Cosway, E. J., White, A. J., Parnell, S. M., Schweighoffer, E., Jolin, H. E., Bacon, A., Rodewald, H. R., Tybulewicz, V., McKenzie, A. N. J., Jenkinson, W. E. & Anderson, G., 11 Mar 2022, In: Science Immunology. 7, 69, 12 p., eabn3286.

  Research output: Contribution to journal › Article › peer-review

  • Eosinophils 100%
  • Thymus Gland 99%
  • Regeneration 86%
  • Interleukin-4 Receptors 25%
  • Natural Killer T-Cells 20%
  7 Citations (Scopus)
• 2021

  FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

  Rota, I. A., Handel, A. E., Maio, S., Klein, F., Dhalla, F., Deadman, M. E., Cheuk, S., Newman, J. A., Michaels, Y. S., Zuklys, S., Prevot, N., Hublitz, P., Charles, P. D., Gkazi, A. S., Adamopoulou, E., Qasim, W., Davies, E. G., Hanson, I., Pagnamenta, A. T., Camps, C., & 11 othersDreau, H. M., White, A., James, K., Fischer, R., Gileadi, O., Taylor, J. C., Fulga, T., Christoffer Lagerholm, B., Anderson, G., Sezgin, E. & Holländer, G. A., 3 Dec 2021, In: Science Advances. 7, 49, 19 p., eabj9247.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epithelial Cells 100%
  • Mutation 78%
  • Primary Immunodeficiency Diseases 63%
  • Lymphopenia 56%
  • Organogenesis 56%
  5 Citations (Scopus)

  2 Downloads (Pure)