Innovative approaches to improving the safety and efficacy of glucocorticoids

Research output

Research output per year 2012 2017 2018

• 16 Article
• 1 Review article

Research output per year

Research output per year

Search results

• Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells

  Rahman, M. M., Rumzhum, N. N., Hansbro, P. M., Morris, J. C., Clark, A., Verrills, N. M. & Ammit, A. J., 26 Jan 2016, (E-pub ahead of print) In: Cellular Signalling.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Protein Phosphatase 2 79%
  • Anti-Inflammatory Agents 44%
  • Epithelial Cells 43%
  • Lung 32%
  28 Citations (Scopus)

  181 Downloads (Pure)

• Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1

  Joanny, E., Ding, Q., Gong, L., Kong, P., Saklatvala, J. & Clark, A., 2012, In: British Journal of Pharmacology. 165, 4b, p. 1124-36 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dual Specificity Phosphatase 1 100%
  • Glucocorticoid Receptors 73%
  • Anti-Inflammatory Agents 48%
  • Up-Regulation 47%
  • Glucocorticoids 30%
  35 Citations (Scopus)

• Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways

  McGuire, V. A., Rosner, D., Ananieva, O., Ross, E. A., Elcombe, S. E., Naqvi, S., van den Bosch, M. M. W., Monk, C. E., Ruiz-Zorrilla Diez, T., Clark, A. R. & Arthur, J. S. C., 1 Jan 2017, In: Molecular and Cellular Biology. 37, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tristetraprolin 100%
  • Interferon-beta 70%
  • p38 Mitogen-Activated Protein Kinases 62%
  • Mitogens 61%
  • Interferons 56%
  8 Citations (Scopus)

• Dominant suppression of inflammation via targeted mutation of the mRNA destabilizing protein tristetraprolin

  Ross, E. A., Smallie, T., Ding, Q., O'neil, J. D., Cunliffe, H. E., Tang, T., Rosner, D. R., Klevernic, I., Morrice, N. A., Monaco, C., Cunningham, A. F., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 265-276

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Inflammation 35%
  • Messenger RNA 34%
  • Mutation 34%
  • Salmonella typhimurium 14%
  49 Citations (Scopus)

  182 Downloads (Pure)

• Dual-specificity phosphatase 1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide

  Smallie, T., Ross, E. A., Ammit, A. J., Cunliffe, H. E., Tang, T., Rosner, D. R., Ridley, M. L., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 277-288

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Dual Specificity Phosphatase 1 92%
  • Innate Immunity 56%
  • Lipopolysaccharides 52%
  • Macrophages 42%
  47 Citations (Scopus)

  206 Downloads (Pure)

• Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

  Vattakuzhi, Y., Abraham, S. M., Freidin, A., Clark, A. & Horwood, N. J., 2012, In: Arthritis & Rheumatism. 64, 7, p. 2201-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mouse Dusp1 protein 100%
  • Osteolysis 52%
  • Experimental Arthritis 51%
  • Osteoclasts 44%
  • p38 Mitogen-Activated Protein Kinases 44%
  24 Citations (Scopus)

• Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.

  O'Neil, J., Ross, E., Ridley, M., Rosner, D., Crowley, T., Smallie, T., Buckley, C. & Clark, A., Jun 2017, In: Molecular and Cellular Biology. 37, 11, e00536-16.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Gain of Function Mutation 80%
  • Anti-Inflammatory Agents 44%
  • Macrophages 42%
  • Interleukin-10 31%
  6 Citations (Scopus)

  183 Downloads (Pure)

• Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

  Ahasan, MM., Hardy, R., Jones, C., Kaur, K., Nanus, D., Juarez, M., Morgan, S., Hassan-Smith, Z., Bénézech, C., Caamaño, JH., Hewison, M., Lavery, G., Rabbitt, E., Clark, AR., Filer, A., Buckley, C., Raza, K., Stewart, P. & Cooper, M., Jul 2012, In: Arthritis & Rheumatism. 67, 7, p. 2404-2413

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Glucocorticoids 62%
  • Mesenchymal Stem Cells 61%
  • Dual Specificity Phosphatase 1 29%
  • Stromal Cells 19%
  33 Citations (Scopus)

  115 Downloads (Pure)

• Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

  Tang, T., Scambler, T. E., Smallie, T., Cunliffe, H. E., Ross, E. A., Rosner, D. R., O’neil, J. D. & Clark, A. R., 1 Dec 2017, In: Scientific Reports. 7, 1, 4350.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Dual Specificity Phosphatase 1 92%
  • Dinoprostone 59%
  • Lipopolysaccharides 52%
  • Macrophages 42%
  28 Citations (Scopus)

  193 Downloads (Pure)

• MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth

  O'Neil, J. D., Ammit, A. J. & Clark, A. R., Jan 2018, In: The International Journal of Biochemistry & Cell Biology. 94, p. 6-9 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • p38 Mitogen-Activated Protein Kinases 62%
  • Gene Expression 36%
  • MAP Kinase Kinase 2 19%
  • MAP Kinase Kinase Kinases 16%
  23 Citations (Scopus)

  172 Downloads (Pure)

• Nonclassical Ly6C(-) Monocytes Drive the Development of Inflammatory Arthritis in Mice

  Misharin, A. V., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Budinger, G. R. S. & Perlman, H., 23 Oct 2014, In: Cell Reports. 9, 2, p. 591-604 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Plastic Property 100%
  • Arthritis 75%
  • Marker 75%
  • Monocytes 71%
  • Polarization 64%
  146 Citations (Scopus)

  309 Downloads (Pure)

• Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

  Crowley, T., O’neil, J. D., Adams, H., Thomas, A. M., Filer, A., Buckley, C. D. & Clark, A., 10 Feb 2017, In: Arthritis Research & Therapy. 19, 35.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fibroblasts 100%
  • Synoviocytes 91%
  • Joints 86%
  • Cytokines 83%
  • Skin 73%
  30 Citations (Scopus)

  178 Downloads (Pure)

• The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

  Clark, A. & Dean, J. L. E., 19 Oct 2016, In: Biochemical Society Transactions. 44, 5, p. 1321-1337

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Dephosphorylation 76%
  • Phosphoric Monoester Hydrolases 61%
  • Phosphorylation 42%
  • Inflammation 35%
  45 Citations (Scopus)

  168 Downloads (Pure)

• The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome

  Haneklaus, M., O'Neil, J. D., Clark, A. R., Masters, S. L. & O'Neill, L. A. J., 28 Apr 2017, In: Journal of Biological Chemistry. 292, 17, p. 6869-6881 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Inflammasomes 73%
  • RNA-Binding Proteins 70%
  • Interleukin-1 48%
  • Cleavage 41%
  28 Citations (Scopus)

  171 Downloads (Pure)

• Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

  Ross, E., Naylor, A., O'Neil, J., Crowley, T., Ridley, M., Crowe, J., Smallie, T., Tang, J. T., Turner, J., Norling, L. V., Dominguez, S., Perlman, H., Verrills, N. M., Kollias, G., Vitek, M. P., Filer, A., Buckley, C., Dean, J. L. & Clark, A., Mar 2017, In: Annals of the Rheumatic Diseases. 76, 3, p. 612-619

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Arthritis 53%
  • Gene Expression 36%
  • Antiinflammatory 29%
  • Dephosphorylation 25%
  43 Citations (Scopus)

  171 Downloads (Pure)

• Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment

  Bulbrook, D., Brazier, H., Mahajan, P., Kliszczak, M., Fedorov, O., Marchese, F. P., Aubareda, A., Chalk, R., Picaud, S., Strain-Damerell, C., Filippakopoulos, P., Gileadi, O., Clark, A. R., Yue, W. W., Burgess-Brown, N. A. & Dean, J. L. E., 29 Dec 2017, (E-pub ahead of print) In: Journal of Molecular Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Repressor Proteins 86%
  • Tryptophan 64%
  • Carbon 60%
  • RNA Stability 22%
  11 Citations (Scopus)

  265 Downloads (Pure)