Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

Youridies Vattakuzhi; Sonya M Abraham; Andrew Freidin; Andy Clark; Nicole J Horwood

doi:10.1002/art.34403

Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

Youridies Vattakuzhi, Sonya M Abraham, Andrew Freidin, Andy Clark, Nicole J Horwood

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Bone formation and destruction are usually tightly linked; however, in disorders such as rheumatoid arthritis, periodontal disease, and osteoporosis, elevated osteoclast activity leads to bone destruction. Osteoclast formation and activation are controlled by many signaling pathways, including p38 MAPK. Dual-specificity phosphatase 1 (DUSP-1) is a factor involved in the negative regulation of p38 MAPK. The purpose of this study was to examine the effect of Dusp1 deficiency on bone destruction.

Original language	English
Pages (from-to)	2201-10
Number of pages	10
Journal	Arthritis & Rheumatism
Volume	64
Issue number	7
DOIs	https://doi.org/10.1002/art.34403
Publication status	Published - 2012

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10.1002/art.34403

Innovative approaches to improving the safety and efficacy of glucocorticoids
Clark, A.
ARTHRITIS RESEARCH CAMPAIGN
1/06/12 → 15/10/17
Project: Research

Cite this

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title = "Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis",

abstract = "Bone formation and destruction are usually tightly linked; however, in disorders such as rheumatoid arthritis, periodontal disease, and osteoporosis, elevated osteoclast activity leads to bone destruction. Osteoclast formation and activation are controlled by many signaling pathways, including p38 MAPK. Dual-specificity phosphatase 1 (DUSP-1) is a factor involved in the negative regulation of p38 MAPK. The purpose of this study was to examine the effect of Dusp1 deficiency on bone destruction.",

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AU - Clark, Andy

AU - Horwood, Nicole J

PY - 2012

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AB - Bone formation and destruction are usually tightly linked; however, in disorders such as rheumatoid arthritis, periodontal disease, and osteoporosis, elevated osteoclast activity leads to bone destruction. Osteoclast formation and activation are controlled by many signaling pathways, including p38 MAPK. Dual-specificity phosphatase 1 (DUSP-1) is a factor involved in the negative regulation of p38 MAPK. The purpose of this study was to examine the effect of Dusp1 deficiency on bone destruction.

U2 - 10.1002/art.34403

DO - 10.1002/art.34403

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JO - Arthritis & Rheumatism

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Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

Abstract

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Innovative approaches to improving the safety and efficacy of glucocorticoids

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