Research output per year
Research output per year
- 17 results
Search results
-
2018
MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth
O'Neil, J. D., Ammit, A. J. & Clark, A. R., Jan 2018, In: The International Journal of Biochemistry & Cell Biology. 94, p. 6-9 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)172 Downloads (Pure) -
The role of microRNAs in glucocorticoid action
Clayton, S. A., Jones, S. W., Kurowska-stolarska, M. & Clark, A. R., 9 Feb 2018, In: Journal of Biological Chemistry. 293, 6, p. 1865-1874Research output: Contribution to journal › Review article › peer-review
Open AccessFile27 Citations (Scopus)281 Downloads (Pure) -
2017
Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways
McGuire, V. A., Rosner, D., Ananieva, O., Ross, E. A., Elcombe, S. E., Naqvi, S., van den Bosch, M. M. W., Monk, C. E., Ruiz-Zorrilla Diez, T., Clark, A. R. & Arthur, J. S. C., 1 Jan 2017, In: Molecular and Cellular Biology. 37, 1Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.
O'Neil, J., Ross, E., Ridley, M., Rosner, D., Crowley, T., Smallie, T., Buckley, C. & Clark, A., Jun 2017, In: Molecular and Cellular Biology. 37, 11, e00536-16.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)183 Downloads (Pure) -
Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin
Tang, T., Scambler, T. E., Smallie, T., Cunliffe, H. E., Ross, E. A., Rosner, D. R., O’neil, J. D. & Clark, A. R., 1 Dec 2017, In: Scientific Reports. 7, 1, 4350.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)193 Downloads (Pure) -
Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts
Crowley, T., O’neil, J. D., Adams, H., Thomas, A. M., Filer, A., Buckley, C. D. & Clark, A., 10 Feb 2017, In: Arthritis Research & Therapy. 19, 35.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)176 Downloads (Pure) -
The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome
Haneklaus, M., O'Neil, J. D., Clark, A. R., Masters, S. L. & O'Neill, L. A. J., 28 Apr 2017, In: Journal of Biological Chemistry. 292, 17, p. 6869-6881 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)171 Downloads (Pure) -
Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression
Ross, E., Naylor, A., O'Neil, J., Crowley, T., Ridley, M., Crowe, J., Smallie, T., Tang, J. T., Turner, J., Norling, L. V., Dominguez, S., Perlman, H., Verrills, N. M., Kollias, G., Vitek, M. P., Filer, A., Buckley, C., Dean, J. L. & Clark, A., Mar 2017, In: Annals of the Rheumatic Diseases. 76, 3, p. 612-619Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)171 Downloads (Pure) -
Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment
Bulbrook, D., Brazier, H., Mahajan, P., Kliszczak, M., Fedorov, O., Marchese, F. P., Aubareda, A., Chalk, R., Picaud, S., Strain-Damerell, C., Filippakopoulos, P., Gileadi, O., Clark, A. R., Yue, W. W., Burgess-Brown, N. A. & Dean, J. L. E., 29 Dec 2017, (E-pub ahead of print) In: Journal of Molecular Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)265 Downloads (Pure) -
2016
Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells
Rahman, M. M., Rumzhum, N. N., Hansbro, P. M., Morris, J. C., Clark, A., Verrills, N. M. & Ammit, A. J., 26 Jan 2016, (E-pub ahead of print) In: Cellular Signalling.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)181 Downloads (Pure) -
The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases
Clark, A. & Dean, J. L. E., 19 Oct 2016, In: Biochemical Society Transactions. 44, 5, p. 1321-1337Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)168 Downloads (Pure) -
2015
Dominant suppression of inflammation via targeted mutation of the mRNA destabilizing protein tristetraprolin
Ross, E. A., Smallie, T., Ding, Q., O'neil, J. D., Cunliffe, H. E., Tang, T., Rosner, D. R., Klevernic, I., Morrice, N. A., Monaco, C., Cunningham, A. F., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 265-276Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)182 Downloads (Pure) -
Dual-specificity phosphatase 1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide
Smallie, T., Ross, E. A., Ammit, A. J., Cunliffe, H. E., Tang, T., Rosner, D. R., Ridley, M. L., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 277-288Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)205 Downloads (Pure) -
2014
Nonclassical Ly6C(-) Monocytes Drive the Development of Inflammatory Arthritis in Mice
Misharin, A. V., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Budinger, G. R. S. & Perlman, H., 23 Oct 2014, In: Cell Reports. 9, 2, p. 591-604 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile146 Citations (Scopus)308 Downloads (Pure) -
2012
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1
Joanny, E., Ding, Q., Gong, L., Kong, P., Saklatvala, J. & Clark, A., 2012, In: British Journal of Pharmacology. 165, 4b, p. 1124-36 13 p.Research output: Contribution to journal › Article › peer-review
35 Citations (Scopus) -
Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis
Vattakuzhi, Y., Abraham, S. M., Freidin, A., Clark, A. & Horwood, N. J., 2012, In: Arthritis & Rheumatism. 64, 7, p. 2201-10 10 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells
Ahasan, MM., Hardy, R., Jones, C., Kaur, K., Nanus, D., Juarez, M., Morgan, S., Hassan-Smith, Z., Bénézech, C., Caamaño, JH., Hewison, M., Lavery, G., Rabbitt, E., Clark, AR., Filer, A., Buckley, C., Raza, K., Stewart, P. & Cooper, M., Jul 2012, In: Arthritis & Rheumatism. 67, 7, p. 2404-2413Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)115 Downloads (Pure)