Sovan Sarkar

Accepting PhD Students

PhD projects

Dr Sarkar is interested in supervising doctoral research in the following areas:

The role and regulation of autophagy in human embryonic stem cells and in differentiated adult cell types
The molecular mechanisms of mammalian autophagy in its role in cellular homeostasis, neurodegeneration, aging and metabolism
Mechanisms of cellular degeneration and proteostasis in disease-relevant human cell types derived from disease-specific induced pluripotent stem cells
Drug discovery in human disease-affected cell types derived from disease-specific induced pluripotent stem cells

Research activity per year

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

Fingerprint

Dive into the research topics where Sovan Sarkar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

1 Similar Profiles

57 Article
4 Review article
1 Working paper

Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models
Kataura, T., Sedlackova, L., Sun, C., Kocak, G., Wilson, N., Banks, P., Hayat, F., Trushin, S., Trushina, E., Maddocks, O. D. K., Oblong, J. E., Miwa, S., Imoto, M., Saiki, S., Erskine, D., Migaud, M. E., Sarkar, S. & Korolchuk, V. I., 31 May 2024, (E-pub ahead of print) In: Cell death & disease. 15, 5, 13 p., 382.
Research output: Contribution to journal › Article › peer-review

Open Access
File
22 Downloads (Pure)
The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival
Stanulović, V. S., Al Omair, S., Reed, M. A. C., Roberts, J., Potluri, S., Fulton-Ward, T., Gudgeon, N., Bishop, E. L., Roels, J., Perry, T. A., Sarkar, S., Pratt, G., Taghon, T., Dimeloe, S., Günther, U. L., Ludwig, C. & Hoogenkamp, M., 30 May 2024, (E-pub ahead of print) In: Haematologica.
Research output: Contribution to journal › Article › peer-review

Open Access
Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons
Korsgen, M. E., Sun, C., Seranova, E., Zatyka, M., Astuti, D., Kataura, T., Barrett, T., Korolchuk, V. I. & Sarkar, S., 25 Aug 2023, (E-pub ahead of print) In: STAR Protocols. 4, 3, 102529.
Research output: Contribution to journal › Article › peer-review

Open Access
File
28 Downloads (Pure)
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome
Zatyka, M., Rosenstock, T. R., Sun, C., Palhegyi, A. M., Hughes, G. W., Lara-Reyna, S., Astuti, D., di Maio, A., Sciauvaud, A., Korsgen, M. E., Stanulovic, V., Kocak, G., Rak, M., Pourtoy-Brasselet, S., Winter, K., Varga, T., Jarrige, M., Polvèche, H., Correia, J., Frickel, E-M., & 5 othersHoogenkamp, M., Ward, D. G., Aubry, L., Barrett, T. & Sarkar, S., 9 May 2023, In: Stem Cell Reports. 18, 5, p. 1090-1106 17 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
42 Downloads (Pure)
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
Sun, C., Seranova, E., Cohen, M. A., Chipara, M., Roberts, J., Astuti, D., Palhegyi, A. M., Acharjee, A., Sedlackova, L., Kataura, T., Otten, E. G., Panda, P. K., Lara-Reyna, S., Korsgen, M. E., Kauffman, K. J., Huerta-Uribe, A., Zatyka, M., Silva, L. F. S. E., Torresi, J., Zhang, S., & 20 othersHughes, G. W., Ward, C., Kuechler, E. R., Cartwright, D., Trushin, S., Trushina, E., Sahay, G., Buganim, Y., Lavery, G. G., Gsponer, J., Anderson, D. G., Frickel, E. M., Rosenstock, T. R., Barrett, T., Maddocks, O. D. K., Tennant, D. A., Wang, H., Jaenisch, R., Korolchuk, V. I. & Sarkar, S., 30 May 2023, In: Cell Reports. 42, 5, 26 p., 112372.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

76 Downloads (Pure)

1 Not started
4 Active
12 Finished

Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases
Barrett, T. & Sarkar, S.
Medical Research Council
1/08/24 → 31/07/27
Project: Research Councils
Repurposing of small molecule enhancers of autophagy for treating ataxia-telangiectasia
Stewart, G., Barrett, T., Sarkar, S. & Tuxworth, R.
ACTION FOR A-T
1/07/24 → 28/02/27
Project: Research
Development of autophagy and NAD enhancers for Wolfram syndrome
Sarkar, S.
Wolfram Syndrome UK
1/05/24 → 30/04/25
Project: Research
LifeArc Pathfinder
Sarkar, S.
LifeArc
1/02/23 → 30/09/24
Project: Research
Combination treatment strategy with autophagy inducer and NAD booster for rare childhood-onset neurodegenerative diseases
Barrett, T. & Sarkar, S.
ACTION MEDICAL RESEARCH
1/11/24 → 31/10/27
Project: Research

Sovan Sarkar

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models

The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival

Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons

Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome

NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

Targeting the autophagy-NAD axis in rare early-onset neurodegenerative diseases

Repurposing of small molecule enhancers of autophagy for treating ataxia-telangiectasia

Development of autophagy and NAD enhancers for Wolfram syndrome

LifeArc Pathfinder

Combination treatment strategy with autophagy inducer and NAD booster for rare childhood-onset neurodegenerative diseases

Sovan Sarkar

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects