Jennifer Heaney

2024

Effects of aerobic and resistance exercise for 9 months on serum free light chains in type 2 diabetes

Kim, Y., Campbell, J., Johannsen, N., Church, T., Cho, E., Heaney, J. & Spielmann , G., 25 Apr 2024, In: Frontiers in Physiology. 15, 13 p., 1328470.

Research output: Contribution to journal › Article › peer-review

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33 Downloads (Pure)

Paracetamol suppresses neutrophilic oxygen radicals through competitive inhibition and scavenging

Smith, P., Chicca, I., Heaney, J., Muchová, M., Khanim, F., Shields, A., Drayson, M., Chapple, I. & Hirschfeld, J., 1 Dec 2024, In: Chemico-Biological Interactions. 404, 8 p., 111283.

Research output: Contribution to journal › Article › peer-review

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50 Downloads (Pure)

Plasma cell disorders supress mucosal anti-bacterial immunity: another dimension of immunoparesis in plasma cell neoplasms

Faustini, S., Chan, Y. L. T., Evans, L., Collman, E., Rapson, A., Backhouse, C., Emery, A., Campbell, J. P., Moore, S., Richter, A., Pratt, G., Drayson, M. & Heaney, J., Nov 2024, In: Leukemia. 38, 11, p. 2501-2504 4 p.

Research output: Contribution to journal › Letter › peer-review

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28 Downloads (Pure)

The effects of short-term, progressive exercise training on disease activity in smouldering multiple myeloma and monoclonal gammopathy of undetermined significance: a single-arm pilot study

Emery, A., Moore, S., Crowe, J., Murray, J., Peacock, O., Thompson, D., Betts, F., Rapps, S., Ross, L., Rothschild-Rodriguez, D., Arana Echarri, A., Davies, R., Lewis, R., Augustine, D., Whiteway, A., Afzal, Z., Heaney, J., Drayson, M., Turner, J. & Campbell, J., 5 Feb 2024, In: BMC Cancer. 24, 1, 18 p., 174.

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2023

Immune responses to COVID-19 booster vaccinations in intensively anti-CD38 antibody treated patients with ultra-high-risk multiple myeloma: results from the Myeloma UK (MUK) nine OPTIMUM trial

PITCH Consortium, Jenner, M. W., Owen, R. G., Pratt, D., Cook, G., Richter, A., Drayson, M. & Kaiser, M. F., 21 May 2023, In: British Journal of Haematology. 201, 5, p. 845-850 6 p.

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Saliva antiviral antibody levels are detectable but correlate poorly with serum antibody levels following SARS-CoV-2 infection and/or vaccination

Faustini, S. E., Cook, A., Hill, H., Al-Taei, S., Heaney, J., Efstathiou, E., Tanner, C., Townsend, N., Ahmed, Z., Dinally, M., Hoque, M., Goodall, M., Stamataki, Z., Plant, T., Chapple, I., Cunningham, A. F., Drayson, M. T., Shields, A. M. & Richter, A. G., Oct 2023, In: Journal of Infection. 87, 4, p. 328-335 8 p.

Research output: Contribution to journal › Article › peer-review

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2022

Impact of Etiological Cytogenetic Abnormalities on the Depth of Immunoparesis and Survival in Newly Diagnosed Multiple Myeloma

Caro, J., Cairns, D., Menzies, T., Boyle, E., Pawlyn, C., Cook, G., Kaiser, M., Walker, B. A., Owen, R., Jackson, G. H., Morgan, G. J., Heaney, J., Drayson, M. T. & Davies, F. E., Apr 2022, In: Clinical Lymphoma Myeloma and Leukemia. 22, 4, p. e279-e284

Research output: Contribution to journal › Article › peer-review

Investigating the utility of saliva immunoglobulins for the detection of myeloma and using myeloma proteins to clarify partition between oral and systemic immunity

Heaney, J., Faustini, S., Evans, L., Rapson, A., Collman, E., Emery, A., Campbell, J. P., Moore, S., Goodall, M., Afzal, Z., Chapple, I., Pratt, G. & Drayson, M., 20 Feb 2022, (E-pub ahead of print) In: European journal of haematology. 108, 6, p. 493-502

Research output: Contribution to journal › Article › peer-review

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2021

Development of a high-sensitivity ELISA detecting IgG, IgA and IgM antibodies to the SARS-CoV-2 spike glycoprotein in serum and saliva

Faustini, S., Jossi, S., Perez-Toledo, M., Shields, A., Allen, J. D., Watanabe, Y., Newby, M. L., Cook, A., Willcox, C., Salim, M., Goodall, M., Heaney, J., Marcial Juarez, E., Morley, G., Torlinska, B., Wraith, D., Veenith, T., Harding, S., Jolles, S. & Mark, P. J. & 8 others, Plant, T., Huissoon, A., O’Shea, M. K., Willcox, B., Drayson, M., Crispin, M., Cunningham, A. & Richter, A., Sept 2021, In: Immunology. 164, 1, p. 135-147 13 p.

Research output: Contribution to journal › Article › peer-review

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2020

ACTH

Heaney, J., 2020, Encyclopedia of Behavioral Medicine. Gellman, M. D. (ed.). Cham: Springer International Publishing Cham, p. 20-20 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Anti-bacterial Antibodies in Multiple Myeloma Patients at Disease Presentation, in Response to Therapy and in Remission: Implications for Patient Management

Chicca, I., Heaney, J., Iqbal, G., Dunn, J., Bowcock, S., Pratt, G., Yong, K., Planche, T., Richter, A. & Drayson, M., 4 Nov 2020, In: Blood Cancer Journal. 10, 11, 114.

Research output: Contribution to journal › Article › peer-review

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Detection of antibodies to the SARS-CoV-2 spike glycoprotein in both serum and saliva enhances detection of infection

Faustini, S. E., Jossi, S. E., Perez-Toledo, M., Shields, A., Allen, J. D., Watanabe, Y., Newby, M. L., Cook, A., Willcox, C. R., Salim, M., Goodall, M., Heaney, J. L., Marcial-Juarez, E., Morley, G. L., Torlinska, B., Wraith, D. C., Veenith, T., Harding, S., Jolles, S. & Mark, P. J. & 8 others, Plant, T., Huissoon, A., O'Shea, M. K., Willcox, B. E., Drayson, M. T., Crispin, M., Cunningham, A. F. & Richter, A. G., 18 Jun 2020, In: medRxiv.

Research output: Contribution to journal › Article › peer-review

Evaluation of two serum free light chain quantitation methods, Freelite and Seralite, in the clinical laboratory with a view to switching immunoassay

Heaney, J., Ackermann, F., Paunet-Bobo, M., Mehlal, S., Jolly, E., Hachem, J., Védrenne, A. & Vasse, M., 16 Jul 2020, (Accepted/In press) In: Clinica Chimica Acta.

Research output: Contribution to journal › Article › peer-review

Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels

Heaney, J., Richter, A., Bowcock, S., Pratt, G., Child, A., Jackson, G., Morgan, G., Truesson, I. & Drayson, M., Apr 2020, In: Haematologica. 105, 4, p. e169-e171 3 p.

Research output: Contribution to journal › Letter › peer-review

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Free light chains as an emerging biomarker in saliva: biological variability and comparisons with salivary IgA and steroid hormones

Rapson, A., Collman, E., Faustini, S., Yonel, Z., Chapple, I., Drayson, M., Richter, A., Campbell, J. P. & Heaney, J., Jan 2020, In: Brain, Behaviour, and Immunity. 83, p. 78-86 9 p.

Research output: Contribution to journal › Article › peer-review

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3 Citations (Scopus)

260 Downloads (Pure)

Salivary free light chains as a new biomarker to measure psychological stress: the impact of a university exam period on salivary immunoglobulins, cortisol, DHEA and symptoms of infection

Irshad, L., Faustini, S., Evans, L., Drayson, M., Campbell, J. P. & Heaney, J., Dec 2020, In: Psychoneuroendocrinology. 122, 104912.

Research output: Contribution to journal › Article › peer-review

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Stratifying risk of infection and response to therapy in patients with myeloma: a prognostic study

Chicca, I. J., Heaney, J. L., Iqbal, G., Dunn, J. A., Bowcock, S., Planche, T., Pratt, G., Yong, K., Low, E., Wood, J., Raynes, K., Higgins, H. & Drayson, M. T., 2020, In: Efficacy and Mechanism Evaluation. 7, 10, p. 1-70

Research output: Contribution to journal › Article › peer-review

2019

Analytical validation of new ELISAs for the quantitation of polyclonal free light chains and comparison to existing assays for healthy and patient samples

Heaney, J., Campbell, J., Goodall, M., Plant, T., Shemar, M., Hand, C. & Drayson, M., 26 Nov 2019, (E-pub ahead of print) In: Journal of Immunological Methods. 112713.

Research output: Contribution to journal › Article › peer-review

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2018

Characterisation of immunoparesis in newly diagnosed myeloma and its impact on progression-free and overall survival in both old and recent myeloma trials

Heaney, J., Campbell, J., Iqbal, G., Cairns, D. A., Richter, A., Child, J. A., Gregory, W. M., Jackson, G., Kaiser, M. F., Owen, R. G., Davies, F. E., Morgan, G. J., Dunn, J. & Drayson, M., Aug 2018, In: Leukemia. 32, 8, p. 1727–1738 12 p.

Research output: Contribution to journal › Article › peer-review

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17 Citations (Scopus)

204 Downloads (Pure)

Intensified training increases salivary free light chains in trained cyclists: indication that training volume increases oral inflammation

Heaney, J., Killer, S., Svendsen, I. S., Gleeson, M. & Campbell, J., May 2018, In: Physiology and Behavior. 188, p. 181-187

Research output: Contribution to journal › Article › peer-review

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3 Citations (Scopus)

309 Downloads (Pure)

2017

Active multiple myeloma suppresses and typically eliminates coexisting MGUS

Campbell, J., Heaney, J., Pandya, S., Afzal, Z., Kaiser, M. F., Owen, R. G., Child, J. A., Gregory, W. M., Morgan, G. J., Jackson, G. H., Bunce, C. & Drayson, M., 20 Jul 2017, (E-pub ahead of print) In: British Journal of Cancer. 117, p. 835-839

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

175 Downloads (Pure)

Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests

Heaney, J., Campbell, J., Griffin, A., Birtwistle, J., Shemar, M., Antony Child, J., Gregory, W. M., Cairns, D. A., Morgan, G. J., Jackson, G. H. & Drayson, M., Jul 2017, In: British Journal of Haematology. 178, 2, p. 220-230

Research output: Contribution to journal › Article › peer-review

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18 Citations (Scopus)

229 Downloads (Pure)

Multiple myeloma can be accurately diagnosed in acute kidney injury patients using a rapid serum free light chain test

Heaney, J., Campbell, J., Yadav, P., Griffin, A., Shemar, M., Pinney, J. & Drayson, M., 20 Jul 2017, In: BMC Nephrology. 18, 247

Research output: Contribution to journal › Article › peer-review

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10 Citations (Scopus)

283 Downloads (Pure)

Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study

Campbell, J., Heaney, J., Pandya, S., Afzal, Z., Kaiser, M. F., Owen, R. G., Child, J. A., Cairns, D. A., Gregory, W. M., Morgan, G. J., Jackson, G. H., Bunce, C. & Drayson, M., Dec 2017, In: The Lancet Haematology. 4, 12, p. e584-e594

Research output: Contribution to journal › Article › peer-review

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4 Citations (Scopus)

188 Downloads (Pure)

2016

Development of a rapid and quantitative lateral flow assay for the simultaneous measurement of serum κ and λ immunoglobulin free light chains (FLC): inception of a new near-patient FLC screening tool

Campbell, J., Heaney, J., Shemar, M., Baldwin, D., Griffin, A., Oldridge , E., Goodall, M., Afzal, Z., Plant , T., Cobbold, M., Jefferis, R., Jacobs, J., Hand, C. & Drayson, M., 9 Aug 2016, (E-pub ahead of print) In: Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journal › Article › peer-review

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20 Citations (Scopus)

631 Downloads (Pure)

Salivary immunoglobulin free light chains: reference ranges and responses to exercise in young and older adults

Heaney, J. L. J., Gleeson, M., Phillips, A. C., Taylor, I. M., Drayson, M. T., Goodall, M., He, C.-S., Svendsen, I. S., Killer, S. C. & Campbell, J., 2016, In: Exercise Immunology Review. 22, p. 28-41 14 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

23 Downloads (Pure)

Serum free light chains are reduced in endurance trained older adults: Evidence that exercise training may reduce basal inflammation in older adults

Heaney, J. L. J., Phillips, A. C., Drayson, M. T. & Campbell, J. P., May 2016, In: Experimental gerontology. 77, p. 69-75 7 p.

Research output: Contribution to journal › Article › peer-review

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5 Citations (Scopus)

228 Downloads (Pure)

The utility of saliva for the assessment of anti-pneumococcal antibodies: investigation of saliva as a marker of antibody status in serum

Heaney, J., Phillips, A., Carroll, D. & Drayson, M., 12 Dec 2016, In: Biomarkers. 23, 2, p. 115-122

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

199 Downloads (Pure)

2015

Salivary Functional Antibody Secretion Is Reduced in Older Adults: A Potential Mechanism of Increased Susceptibility to Bacterial Infection in the Elderly

Heaney, J. L. J., Phillips, A. C., Carroll, D. & Drayson, M. T., 2015, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 70, 12, p. 1578-1585 8 p.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

70 Downloads (Pure)

2014

Physical activity, life events stress, cortisol, and DHEA in older adults: Preliminary findings that physical activity may buffer against the negative effects of stress

Heaney, J. L. J., Carroll, D. & Phillips, A. C., Oct 2014, In: Journal of aging and physical activity. 22, 4, p. 465-473 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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30 Citations (Scopus)

6860 Downloads (Pure)

2013

Relationships and Cardiovascular Risk: Perceived Spousal Ambivalence in Specific Relationship Contexts and its Links to Inflammation

Uchino, B., Bosch, J., Smith, T., Carlisle, M., Birmingham, W., Bowen, K., Light, K., Heaney, J. & O Hartaigh, B., 2013, In: Health Psychology. 32, 10, p. 1067-1075

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

2012