What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research

Research output: Contribution to journalArticlepeer-review

Standard

What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research. / Hoitzing, Hanne; Johnston, Iain G; Jones, Nick S.

In: BioEssays, Vol. 37, No. 6, 06.2015, p. 687-700.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{721cfc375ca14263a7f24fdd391cf07a,
title = "What is the function of mitochondrial networks?: A theoretical assessment of hypotheses and proposal for future research",
abstract = "Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non-linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes.",
author = "Hanne Hoitzing and Johnston, {Iain G} and Jones, {Nick S}",
note = "{\textcopyright} 2015 The Authors. Bioessays published by WILEY Periodicals, Inc.",
year = "2015",
month = jun,
doi = "10.1002/bies.201400188",
language = "English",
volume = "37",
pages = "687--700",
journal = "BioEssays",
issn = "0265-9247",
publisher = "Wiley-VCH Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - What is the function of mitochondrial networks?

T2 - A theoretical assessment of hypotheses and proposal for future research

AU - Hoitzing, Hanne

AU - Johnston, Iain G

AU - Jones, Nick S

N1 - © 2015 The Authors. Bioessays published by WILEY Periodicals, Inc.

PY - 2015/6

Y1 - 2015/6

N2 - Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non-linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes.

AB - Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non-linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes.

U2 - 10.1002/bies.201400188

DO - 10.1002/bies.201400188

M3 - Article

C2 - 25847815

VL - 37

SP - 687

EP - 700

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 6

ER -