Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis

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Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension : a UK cohort study analysis. / Sofianopoulou, E; Kaptoge, S; Graf, S; Hadinnapola, C; Treacy, CM; Church, C; Coghlan, G; Gibbs, JSR; Haimel, M; Howard, L; Johnson, M; Kiely, DG; Lawrie, A; Lordan, J; MacKenzie Ross, RV; Martin, JM; Moledina, S; Newnham, Michael; Peacock, AJ; Price, L; Rhodes, CJ; Suntharalingam, J; Swietlik, EM; Toshner, MR; Wharton, J; Wilkins, MR; Wort, SJ; Pepke-Zaba, J; Condliffe, R; Corris, PA; Di Angelantonio, E ; Provencher, S; Morrell, NW.

In: The European respiratory journal, Vol. 53, No. 5, 1801429, 30.05.2019.

Research output: Contribution to journalArticle

Harvard

Sofianopoulou, E, Kaptoge, S, Graf, S, Hadinnapola, C, Treacy, CM, Church, C, Coghlan, G, Gibbs, JSR, Haimel, M, Howard, L, Johnson, M, Kiely, DG, Lawrie, A, Lordan, J, MacKenzie Ross, RV, Martin, JM, Moledina, S, Newnham, M, Peacock, AJ, Price, L, Rhodes, CJ, Suntharalingam, J, Swietlik, EM, Toshner, MR, Wharton, J, Wilkins, MR, Wort, SJ, Pepke-Zaba, J, Condliffe, R, Corris, PA, Di Angelantonio, E, Provencher, S & Morrell, NW 2019, 'Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis', The European respiratory journal, vol. 53, no. 5, 1801429. https://doi.org/10.1183/13993003.01429-2018

APA

Sofianopoulou, E., Kaptoge, S., Graf, S., Hadinnapola, C., Treacy, CM., Church, C., Coghlan, G., Gibbs, JSR., Haimel, M., Howard, L., Johnson, M., Kiely, DG., Lawrie, A., Lordan, J., MacKenzie Ross, RV., Martin, JM., Moledina, S., Newnham, M., Peacock, AJ., ... Morrell, NW. (2019). Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis. The European respiratory journal, 53(5), [1801429]. https://doi.org/10.1183/13993003.01429-2018

Vancouver

Author

Sofianopoulou, E ; Kaptoge, S ; Graf, S ; Hadinnapola, C ; Treacy, CM ; Church, C ; Coghlan, G ; Gibbs, JSR ; Haimel, M ; Howard, L ; Johnson, M ; Kiely, DG ; Lawrie, A ; Lordan, J ; MacKenzie Ross, RV ; Martin, JM ; Moledina, S ; Newnham, Michael ; Peacock, AJ ; Price, L ; Rhodes, CJ ; Suntharalingam, J ; Swietlik, EM ; Toshner, MR ; Wharton, J ; Wilkins, MR ; Wort, SJ ; Pepke-Zaba, J ; Condliffe, R ; Corris, PA ; Di Angelantonio, E ; Provencher, S ; Morrell, NW. / Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension : a UK cohort study analysis. In: The European respiratory journal. 2019 ; Vol. 53, No. 5.

Bibtex

@article{d780280ba2c24312b4f1860e2eae9372,
title = "Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis",
abstract = "While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter ≤2.5 μm3 (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK PAH national Cohort study. Associations with transplant-free survival and pulmonary hemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (Unadjusted hazard ratio (HR) 2.68; 95% CI 1.11-6.47 per 3 μg·m-3, p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38; 95% CI 1.44-13.36 per 3 μg·m-3, p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival Conversely, indirect measures of exposure to traffic-related air pollution within the 500-1000 m buffer zones correlated with the ERS/ESC risk categories as well as pulmonary hemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.",
keywords = ": pulmonary hypertension, pulmonary arterial hypertension, air pollution, traffic pollution, prognosis, pulmonary vascular resistance",
author = "E Sofianopoulou and S Kaptoge and S Graf and C Hadinnapola and CM Treacy and C Church and G Coghlan and JSR Gibbs and M Haimel and L Howard and M Johnson and DG Kiely and A Lawrie and J Lordan and {MacKenzie Ross}, RV and JM Martin and S Moledina and Michael Newnham and AJ Peacock and L Price and CJ Rhodes and J Suntharalingam and EM Swietlik and MR Toshner and J Wharton and MR Wilkins and SJ Wort and J Pepke-Zaba and R Condliffe and PA Corris and {Di Angelantonio}, E and S Provencher and NW Morrell",
year = "2019",
month = may,
day = "30",
doi = "10.1183/13993003.01429-2018",
language = "English",
volume = "53",
journal = "The European respiratory journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",

}

RIS

TY - JOUR

T1 - Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension

T2 - a UK cohort study analysis

AU - Sofianopoulou, E

AU - Kaptoge, S

AU - Graf, S

AU - Hadinnapola, C

AU - Treacy, CM

AU - Church, C

AU - Coghlan, G

AU - Gibbs, JSR

AU - Haimel, M

AU - Howard, L

AU - Johnson, M

AU - Kiely, DG

AU - Lawrie, A

AU - Lordan, J

AU - MacKenzie Ross, RV

AU - Martin, JM

AU - Moledina, S

AU - Newnham, Michael

AU - Peacock, AJ

AU - Price, L

AU - Rhodes, CJ

AU - Suntharalingam, J

AU - Swietlik, EM

AU - Toshner, MR

AU - Wharton, J

AU - Wilkins, MR

AU - Wort, SJ

AU - Pepke-Zaba, J

AU - Condliffe, R

AU - Corris, PA

AU - Di Angelantonio, E

AU - Provencher, S

AU - Morrell, NW

PY - 2019/5/30

Y1 - 2019/5/30

N2 - While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter ≤2.5 μm3 (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK PAH national Cohort study. Associations with transplant-free survival and pulmonary hemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (Unadjusted hazard ratio (HR) 2.68; 95% CI 1.11-6.47 per 3 μg·m-3, p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38; 95% CI 1.44-13.36 per 3 μg·m-3, p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival Conversely, indirect measures of exposure to traffic-related air pollution within the 500-1000 m buffer zones correlated with the ERS/ESC risk categories as well as pulmonary hemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.

AB - While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter ≤2.5 μm3 (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK PAH national Cohort study. Associations with transplant-free survival and pulmonary hemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (Unadjusted hazard ratio (HR) 2.68; 95% CI 1.11-6.47 per 3 μg·m-3, p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38; 95% CI 1.44-13.36 per 3 μg·m-3, p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival Conversely, indirect measures of exposure to traffic-related air pollution within the 500-1000 m buffer zones correlated with the ERS/ESC risk categories as well as pulmonary hemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.

KW - : pulmonary hypertension

KW - pulmonary arterial hypertension

KW - air pollution

KW - traffic pollution

KW - prognosis

KW - pulmonary vascular resistance

UR - http://www.scopus.com/inward/record.url?scp=85067266500&partnerID=8YFLogxK

U2 - 10.1183/13993003.01429-2018

DO - 10.1183/13993003.01429-2018

M3 - Article

VL - 53

JO - The European respiratory journal

JF - The European respiratory journal

SN - 0903-1936

IS - 5

M1 - 1801429

ER -