The relationship between albuminuria, MCP-1/CCL2 and interstitial macrophages in chronic kidney disease

KS Eardley; D Zehnder; MO Quinkler; J Lepenies; Ruth Bates; Caroline Savage; AJ Howie; Dwomoa Adu; Paul Cockwell

doi:10.1038/sj.ki.5000212

The relationship between albuminuria, MCP-1/CCL2 and interstitial macrophages in chronic kidney disease

KS Eardley, D Zehnder, MO Quinkler, J Lepenies, Ruth Bates, Caroline Savage, AJ Howie, Dwomoa Adu, Paul Cockwell

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Abstract

Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin-creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P

Original language	English
Pages (from-to)	1189-1197
Number of pages	9
Journal	Kidney International
Volume	69
DOIs	https://doi.org/10.1038/sj.ki.5000212
Publication status	Published - 15 Feb 2006

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abstract = "Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin-creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P",

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AU - Zehnder, D

AU - Quinkler, MO

AU - Lepenies, J

AU - Bates, Ruth

AU - Savage, Caroline

AU - Howie, AJ

AU - Adu, Dwomoa

AU - Cockwell, Paul

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The relationship between albuminuria, MCP-1/CCL2 and interstitial macrophages in chronic kidney disease

Abstract

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