The relationship between albuminuria, MCP-1/CCL2 and interstitial macrophages in chronic kidney disease

KS Eardley, D Zehnder, MO Quinkler, J Lepenies, Ruth Bates, Caroline Savage, AJ Howie, Dwomoa Adu, Paul Cockwell

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin-creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P
Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
JournalKidney International
Volume69
DOIs
Publication statusPublished - 15 Feb 2006

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