TY - JOUR
T1 - The relationship between albuminuria, MCP-1/CCL2 and interstitial macrophages in chronic kidney disease
AU - Eardley, KS
AU - Zehnder, D
AU - Quinkler, MO
AU - Lepenies, J
AU - Bates, Ruth
AU - Savage, Caroline
AU - Howie, AJ
AU - Adu, Dwomoa
AU - Cockwell, Paul
PY - 2006/2/15
Y1 - 2006/2/15
N2 - Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin-creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P
AB - Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin-creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P
UR - http://www.scopus.com/inward/record.url?scp=33645525811&partnerID=8YFLogxK
U2 - 10.1038/sj.ki.5000212
DO - 10.1038/sj.ki.5000212
M3 - Article
C2 - 16609683
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
SN - 1523-1755
VL - 69
SP - 1189
EP - 1197
JO - Kidney International
JF - Kidney International
ER -