The ever-expanding myokinome: discovery challenges and therapeutic implications

Martin Whitham; Mark A Febbraio

doi:10.1038/nrd.2016.153

The ever-expanding myokinome: discovery challenges and therapeutic implications

Martin Whitham, Mark A Febbraio

Sport, Exercise and Rehabilitation Sciences

Research output: Contribution to journal › Review article › peer-review

112 Citations (Scopus)

Abstract

Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but the molecular mechanisms mediating the protective effects of exercise are not completely understood. The realization that skeletal muscle is an endocrine organ capable of secreting proteins termed 'myokines', which participate in tissue crosstalk, provided a critical link in the exercise-health paradigm. However, the myokine field is still emerging, and several challenges remain in the discovery and validation of myokines. This Review considers these challenges and highlights some recently identified novel myokines with the potential to be therapeutically exploited in the treatment of metabolic disease and cancer.

Original language	English
Pages (from-to)	719-29
Number of pages	11
Journal	Nature reviews. Drug discovery
Volume	15
Issue number	10
Early online date	12 Sept 2016
DOIs	https://doi.org/10.1038/nrd.2016.153
Publication status	Published - Oct 2016

Keywords

Animals
Drug Discovery/methods
Exercise/physiology
Humans
Interleukin-6/metabolism
Metabolic Diseases/drug therapy
Muscle Proteins/metabolism
Muscle, Skeletal/drug effects
Neoplasms/drug therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrd.2016.153

Cite this

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abstract = "Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but the molecular mechanisms mediating the protective effects of exercise are not completely understood. The realization that skeletal muscle is an endocrine organ capable of secreting proteins termed 'myokines', which participate in tissue crosstalk, provided a critical link in the exercise-health paradigm. However, the myokine field is still emerging, and several challenges remain in the discovery and validation of myokines. This Review considers these challenges and highlights some recently identified novel myokines with the potential to be therapeutically exploited in the treatment of metabolic disease and cancer.",

keywords = "Animals, Drug Discovery/methods, Exercise/physiology, Humans, Interleukin-6/metabolism, Metabolic Diseases/drug therapy, Muscle Proteins/metabolism, Muscle, Skeletal/drug effects, Neoplasms/drug therapy",

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KW - Drug Discovery/methods

KW - Exercise/physiology

KW - Humans

KW - Interleukin-6/metabolism

KW - Metabolic Diseases/drug therapy

KW - Muscle Proteins/metabolism

KW - Muscle, Skeletal/drug effects

KW - Neoplasms/drug therapy

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EP - 729

JO - Nature reviews. Drug discovery

JF - Nature reviews. Drug discovery

IS - 10

ER -

The ever-expanding myokinome: discovery challenges and therapeutic implications

Abstract

Keywords

UN SDGs

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