The ever-expanding myokinome: discovery challenges and therapeutic implications

Martin Whitham, Mark A Febbraio

Research output: Contribution to journalReview articlepeer-review

112 Citations (Scopus)


Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but the molecular mechanisms mediating the protective effects of exercise are not completely understood. The realization that skeletal muscle is an endocrine organ capable of secreting proteins termed 'myokines', which participate in tissue crosstalk, provided a critical link in the exercise-health paradigm. However, the myokine field is still emerging, and several challenges remain in the discovery and validation of myokines. This Review considers these challenges and highlights some recently identified novel myokines with the potential to be therapeutically exploited in the treatment of metabolic disease and cancer.

Original languageEnglish
Pages (from-to)719-29
Number of pages11
JournalNature reviews. Drug discovery
Issue number10
Early online date12 Sept 2016
Publication statusPublished - Oct 2016


  • Animals
  • Drug Discovery/methods
  • Exercise/physiology
  • Humans
  • Interleukin-6/metabolism
  • Metabolic Diseases/drug therapy
  • Muscle Proteins/metabolism
  • Muscle, Skeletal/drug effects
  • Neoplasms/drug therapy


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