The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers
Research output: Contribution to journal › Review article
Colleges, School and Institutes
- Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. firstname.lastname@example.org.
- Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. L.S.Young@warwick.ac.uk.
- Oral Cancer Research and Coordinating Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia. email@example.com.
- Oral Cancer Research and Coordinating Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia. firstname.lastname@example.org.
The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.
|Number of pages||23|
|Publication status||Published - 27 Jul 2018|
- TGF-β signalling, Epstein-Barr virus, nasopharyngeal carcinoma, gastric cancer, B-cell lymphoma