The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

External organisations

  • Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. vsharmila84@gmail.com.
  • Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. L.S.Young@warwick.ac.uk.
  • Oral Cancer Research and Coordinating Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia. ipaterson@um.edu.my.
  • Oral Cancer Research and Coordinating Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia. yapleefah@um.edu.my.

Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

Details

Original languageEnglish
Article number247
Number of pages23
JournalCancers
Volume10
Issue number8
Publication statusPublished - 27 Jul 2018

Keywords

  • TGF-β signalling, Epstein-Barr virus, nasopharyngeal carcinoma, gastric cancer, B-cell lymphoma