The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Sharmila Velapasamy, Christopher W Dawson, Lawrence S Young, Ian C Paterson, Lee Fah Yap

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
133 Downloads (Pure)

Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

Original languageEnglish
Article number247
Number of pages23
JournalCancers
Volume10
Issue number8
DOIs
Publication statusPublished - 27 Jul 2018

Keywords

  • TGF-β signalling
  • Epstein-Barr virus
  • nasopharyngeal carcinoma
  • gastric cancer
  • B-cell lymphoma

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