The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Sharmila Velapasamy; Christopher W Dawson; Lawrence S Young; Ian C Paterson; Lee Fah Yap

doi:10.3390/cancers10080247

The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Sharmila Velapasamy, Christopher W Dawson, Lawrence S Young, Ian C Paterson, Lee Fah Yap

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

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Abstract

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

Original language	English
Article number	247
Number of pages	23
Journal	Cancers
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/cancers10080247
Publication status	Published - 27 Jul 2018

Keywords

TGF-β signalling
Epstein-Barr virus
nasopharyngeal carcinoma
gastric cancer
B-cell lymphoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Sharmila_Velapasamy_et_al_The_Dynamic_Roles_of_TGF-β_Cancers_2018
Checked for eligibility: 06/08/2018
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Cite this

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title = "The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers",

abstract = "The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.",

keywords = "TGF-β signalling, Epstein-Barr virus, nasopharyngeal carcinoma, gastric cancer, B-cell lymphoma",

author = "Sharmila Velapasamy and Dawson, {Christopher W} and Young, {Lawrence S} and Paterson, {Ian C} and Yap, {Lee Fah}",

year = "2018",

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T1 - The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

AU - Velapasamy, Sharmila

AU - Dawson, Christopher W

AU - Young, Lawrence S

AU - Paterson, Ian C

AU - Yap, Lee Fah

PY - 2018/7/27

Y1 - 2018/7/27

N2 - The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

AB - The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting tumour progression in the later stages of disease. Consequently, the functional outcome of TGF-β signalling is strongly context-dependent and is influenced by various factors including cell, tissue and cancer type. Disruption of this pathway can be caused by various means, including genetic and environmental factors. A number of human viruses have been shown to modulate TGF-β signalling during tumorigenesis. In this review, we describe how this pathway is perturbed in Epstein-Barr virus (EBV)-associated cancers and how EBV interferes with TGF-β signal transduction. The role of TGF-β in regulating the EBV life cycle in tumour cells is also discussed.

KW - TGF-β signalling

KW - Epstein-Barr virus

KW - nasopharyngeal carcinoma

KW - gastric cancer

KW - B-cell lymphoma

U2 - 10.3390/cancers10080247

DO - 10.3390/cancers10080247

M3 - Review article

C2 - 30060514

SN - 2072-6694

VL - 10

JO - Cancers

JF - Cancers

IS - 8

M1 - 247

ER -

The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers

Abstract

Keywords

UN SDGs

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