The chromosome 9 ALS and FTD locus is probably derived from a single founder

K Mok; BJ Traynor; J Schymick; PJ Tienari; H Laaksovirta; T Peuralinna; L Myllykangas; A Chio; A Shatunov; BF Boeve; AL Boxer; M DeJesus-Hernandez; IR Mackenzie; A Waite; N Williams; HR Morris; J Simon-Sanchez; JC van Swieten; P Heutink; G Restagno; G Mora; Karen Morrison; PJ Shaw; PS Rollinson; A Al-Chalabi; R Rademakers; S Pickering-Brown; RW Orrell; MA Nalls; J Hardy

doi:10.1016/j.neurobiolaging.2011.08.005

The chromosome 9 ALS and FTD locus is probably derived from a single founder

K Mok, BJ Traynor, J Schymick, PJ Tienari, H Laaksovirta, T Peuralinna, L Myllykangas, A Chio, A Shatunov, BF Boeve, AL Boxer, M DeJesus-Hernandez, IR Mackenzie, A Waite, N Williams, HR Morris, J Simon-Sanchez, JC van Swieten, P Heutink, G RestagnoG Mora, Karen Morrison, PJ Shaw, PS Rollinson, A Al-Chalabi, R Rademakers, S Pickering-Brown, RW Orrell, MA Nalls, J Hardy

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Abstract

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	209.e3
Number of pages	1
Journal	Neurobiology of Aging
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2011.08.005
Publication status	Published - 1 Jan 2012

Keywords

Genetics
Frontotemporal dementia
Amyotrophic lateral sclerosis
Finland

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10.1016/j.neurobiolaging.2011.08.005

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Mok, K., Traynor, BJ., Schymick, J., Tienari, PJ., Laaksovirta, H., Peuralinna, T., Myllykangas, L., Chio, A., Shatunov, A., Boeve, BF., Boxer, AL., DeJesus-Hernandez, M., Mackenzie, IR., Waite, A., Williams, N., Morris, HR., Simon-Sanchez, J., van Swieten, JC., Heutink, P., ... Hardy, J. (2012). The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Aging, 33(1), 209.e3. https://doi.org/10.1016/j.neurobiolaging.2011.08.005

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title = "The chromosome 9 ALS and FTD locus is probably derived from a single founder",

abstract = "We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.",

keywords = "Genetics, Frontotemporal dementia, Amyotrophic lateral sclerosis, Finland",

author = "K Mok and BJ Traynor and J Schymick and PJ Tienari and H Laaksovirta and T Peuralinna and L Myllykangas and A Chio and A Shatunov and BF Boeve and AL Boxer and M DeJesus-Hernandez and IR Mackenzie and A Waite and N Williams and HR Morris and J Simon-Sanchez and {van Swieten}, JC and P Heutink and G Restagno and G Mora and Karen Morrison and PJ Shaw and PS Rollinson and A Al-Chalabi and R Rademakers and S Pickering-Brown and RW Orrell and MA Nalls and J Hardy",

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Mok, K, Traynor, BJ, Schymick, J, Tienari, PJ, Laaksovirta, H, Peuralinna, T, Myllykangas, L, Chio, A, Shatunov, A, Boeve, BF, Boxer, AL, DeJesus-Hernandez, M, Mackenzie, IR, Waite, A, Williams, N, Morris, HR, Simon-Sanchez, J, van Swieten, JC, Heutink, P, Restagno, G, Mora, G, Morrison, K, Shaw, PJ, Rollinson, PS, Al-Chalabi, A, Rademakers, R, Pickering-Brown, S, Orrell, RW, Nalls, MA & Hardy, J 2012, 'The chromosome 9 ALS and FTD locus is probably derived from a single founder', Neurobiology of Aging, vol. 33, no. 1, pp. 209.e3. https://doi.org/10.1016/j.neurobiolaging.2011.08.005

TY - JOUR

T1 - The chromosome 9 ALS and FTD locus is probably derived from a single founder

AU - Mok, K

AU - Traynor, BJ

AU - Schymick, J

AU - Tienari, PJ

AU - Laaksovirta, H

AU - Peuralinna, T

AU - Myllykangas, L

AU - Chio, A

AU - Shatunov, A

AU - Boeve, BF

AU - Boxer, AL

AU - DeJesus-Hernandez, M

AU - Mackenzie, IR

AU - Waite, A

AU - Williams, N

AU - Morris, HR

AU - Simon-Sanchez, J

AU - van Swieten, JC

AU - Heutink, P

AU - Restagno, G

AU - Mora, G

AU - Morrison, Karen

AU - Shaw, PJ

AU - Rollinson, PS

AU - Al-Chalabi, A

AU - Rademakers, R

AU - Pickering-Brown, S

AU - Orrell, RW

AU - Nalls, MA

AU - Hardy, J

PY - 2012/1/1

Y1 - 2012/1/1

N2 - We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.

AB - We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.

KW - Genetics

KW - Frontotemporal dementia

KW - Amyotrophic lateral sclerosis

KW - Finland

U2 - 10.1016/j.neurobiolaging.2011.08.005

DO - 10.1016/j.neurobiolaging.2011.08.005

M3 - Article

C2 - 21925771

VL - 33

SP - 209.e3

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 1

ER -

The chromosome 9 ALS and FTD locus is probably derived from a single founder

Abstract

Keywords

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