The chromosome 9 ALS and FTD locus is probably derived from a single founder

K Mok, BJ Traynor, J Schymick, PJ Tienari, H Laaksovirta, T Peuralinna, L Myllykangas, A Chio, A Shatunov, BF Boeve, AL Boxer, M DeJesus-Hernandez, IR Mackenzie, A Waite, N Williams, HR Morris, J Simon-Sanchez, JC van Swieten, P Heutink, G RestagnoG Mora, Karen Morrison, PJ Shaw, PS Rollinson, A Al-Chalabi, R Rademakers, S Pickering-Brown, RW Orrell, MA Nalls, J Hardy

    Research output: Contribution to journalArticle

    93 Citations (Scopus)


    We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. (C) 2012 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)209.e3
    Number of pages1
    JournalNeurobiology of Aging
    Issue number1
    Publication statusPublished - 1 Jan 2012


    • Genetics
    • Frontotemporal dementia
    • Amyotrophic lateral sclerosis
    • Finland


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