Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

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Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD. / Pan, Jing; Xu, Lin; Lam, Tai Hing; Jiang, Chao Qiang; Zhang, Wei Sen; Zhu, Xiao-Feng; Jin, Ya Li; Thomas, G Neil; Cheng, Kar; Adab, Peymane.

In: BMC Pulmonary Medicine, Vol. 18, No. 74, 21.05.2018.

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Pan, Jing ; Xu, Lin ; Lam, Tai Hing ; Jiang, Chao Qiang ; Zhang, Wei Sen ; Zhu, Xiao-Feng ; Jin, Ya Li ; Thomas, G Neil ; Cheng, Kar ; Adab, Peymane. / Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD. In: BMC Pulmonary Medicine. 2018 ; Vol. 18, No. 74.

Bibtex

@article{53182a4c665a4c218c986a96248788cd,
title = "Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD",
abstract = "Background: Findings describing the relationship between pulmonary function and peripheral vascular function have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD). Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform analyser, and pulmonary function by turbine flowmeter spirometry. Predicted forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were derived using equations for Chinese. Regression analyses were used to investigate the association. Results: Of 1528 older Chinese, 980 (64.1%) had arterial stiffness (baPWV ≥1400 cm/s), but only 29 (1.9%) had peripheral arterial disease (PAD) (ABI < 0.9). The mean (±standard deviation, SD) baPWV was 1547 (±298) cm/s and mean (±SD) ABI 1.09 (±0.09). Before and after adjusting for potential confounders, baPWV was negatively associated with FEV1 and FVC % predicted (% predicted = observed/predicted × 100%) (adjusted β: − 0.95 and − 1.16 respectively, p < 0.05), and ABI was marginally non-significantly positively associated with FEV1% predicted (adjusted β 0.02, p = 0.32) and FVC% predicted (adjusted β 0.02, p = 0.18). Compared to participants in the highest tertile of pulmonary function, those in the lowest had higher risk of arterial stiffness (adjusted odds ratio (AOR) 1. 51, 95% CI 1.09–2.10 for FEV1 and AOR 1.69, 95% CI 1.22–2.33 for FVC), but the higher risk of PAD was marginally non-significant (AOR 1.64, p = 0.42 for FEV1 and AOR 1.65, p = 0.24 for FVC). Conclusion: In older relatively healthy normal weight Chinese, pulmonary function was inversely dose-dependently associated with arterial stiffness, while the association with PAD was much weaker. Keywords: Pulmonary function, Arterial stiffness, Peripheral arterial disease (PAD), Vascular function",
keywords = "Pulmonary function, Arterial stiffness, Peripheral arterial disease (PAD, Vascular function",
author = "Jing Pan and Lin Xu and Lam, {Tai Hing} and Jiang, {Chao Qiang} and Zhang, {Wei Sen} and Xiao-Feng Zhu and Jin, {Ya Li} and Thomas, {G Neil} and Kar Cheng and Peymane Adab",
year = "2018",
month = may,
day = "21",
doi = "10.1186/s12890-018-0649-x",
language = "English",
volume = "18",
journal = "BMC Pulmonary Medicine",
issn = "1471-2466",
publisher = "Springer",
number = "74",

}

RIS

TY - JOUR

T1 - Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

AU - Pan, Jing

AU - Xu, Lin

AU - Lam, Tai Hing

AU - Jiang, Chao Qiang

AU - Zhang, Wei Sen

AU - Zhu, Xiao-Feng

AU - Jin, Ya Li

AU - Thomas, G Neil

AU - Cheng, Kar

AU - Adab, Peymane

PY - 2018/5/21

Y1 - 2018/5/21

N2 - Background: Findings describing the relationship between pulmonary function and peripheral vascular function have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD). Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform analyser, and pulmonary function by turbine flowmeter spirometry. Predicted forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were derived using equations for Chinese. Regression analyses were used to investigate the association. Results: Of 1528 older Chinese, 980 (64.1%) had arterial stiffness (baPWV ≥1400 cm/s), but only 29 (1.9%) had peripheral arterial disease (PAD) (ABI < 0.9). The mean (±standard deviation, SD) baPWV was 1547 (±298) cm/s and mean (±SD) ABI 1.09 (±0.09). Before and after adjusting for potential confounders, baPWV was negatively associated with FEV1 and FVC % predicted (% predicted = observed/predicted × 100%) (adjusted β: − 0.95 and − 1.16 respectively, p < 0.05), and ABI was marginally non-significantly positively associated with FEV1% predicted (adjusted β 0.02, p = 0.32) and FVC% predicted (adjusted β 0.02, p = 0.18). Compared to participants in the highest tertile of pulmonary function, those in the lowest had higher risk of arterial stiffness (adjusted odds ratio (AOR) 1. 51, 95% CI 1.09–2.10 for FEV1 and AOR 1.69, 95% CI 1.22–2.33 for FVC), but the higher risk of PAD was marginally non-significant (AOR 1.64, p = 0.42 for FEV1 and AOR 1.65, p = 0.24 for FVC). Conclusion: In older relatively healthy normal weight Chinese, pulmonary function was inversely dose-dependently associated with arterial stiffness, while the association with PAD was much weaker. Keywords: Pulmonary function, Arterial stiffness, Peripheral arterial disease (PAD), Vascular function

AB - Background: Findings describing the relationship between pulmonary function and peripheral vascular function have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD). Methods: Brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform analyser, and pulmonary function by turbine flowmeter spirometry. Predicted forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were derived using equations for Chinese. Regression analyses were used to investigate the association. Results: Of 1528 older Chinese, 980 (64.1%) had arterial stiffness (baPWV ≥1400 cm/s), but only 29 (1.9%) had peripheral arterial disease (PAD) (ABI < 0.9). The mean (±standard deviation, SD) baPWV was 1547 (±298) cm/s and mean (±SD) ABI 1.09 (±0.09). Before and after adjusting for potential confounders, baPWV was negatively associated with FEV1 and FVC % predicted (% predicted = observed/predicted × 100%) (adjusted β: − 0.95 and − 1.16 respectively, p < 0.05), and ABI was marginally non-significantly positively associated with FEV1% predicted (adjusted β 0.02, p = 0.32) and FVC% predicted (adjusted β 0.02, p = 0.18). Compared to participants in the highest tertile of pulmonary function, those in the lowest had higher risk of arterial stiffness (adjusted odds ratio (AOR) 1. 51, 95% CI 1.09–2.10 for FEV1 and AOR 1.69, 95% CI 1.22–2.33 for FVC), but the higher risk of PAD was marginally non-significant (AOR 1.64, p = 0.42 for FEV1 and AOR 1.65, p = 0.24 for FVC). Conclusion: In older relatively healthy normal weight Chinese, pulmonary function was inversely dose-dependently associated with arterial stiffness, while the association with PAD was much weaker. Keywords: Pulmonary function, Arterial stiffness, Peripheral arterial disease (PAD), Vascular function

KW - Pulmonary function

KW - Arterial stiffness

KW - Peripheral arterial disease (PAD

KW - Vascular function

U2 - 10.1186/s12890-018-0649-x

DO - 10.1186/s12890-018-0649-x

M3 - Article

VL - 18

JO - BMC Pulmonary Medicine

JF - BMC Pulmonary Medicine

SN - 1471-2466

IS - 74

ER -