Pyruvate kinase, inflammation and periodontal disease
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.
|Number of pages||6|
|Publication status||Published - 22 Jun 2021|
- glycolysis, inflammation, pyruvate kinase, regulation