Pyruvate kinase, inflammation and periodontal disease

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Abstract

Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.
Original languageEnglish
Pages (from-to)784
Number of pages6
JournalPathogens
Volume10
Issue number7
DOIs
Publication statusPublished - 22 Jun 2021

Keywords

  • glycolysis
  • inflammation
  • pyruvate kinase
  • regulation

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