Pyruvate kinase, inflammation and periodontal disease

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Pyruvate kinase (PK) is the final and rate-limiting enzyme in glycolysis. It has four isoforms PKM1, PKM2, PKL and PKR. PK can form homo tetramers, dimers or monomers. The tetrameric form has the most catalytic activity; however, the dimeric form has non-canonical functions that contribute to the inflammatory response, wound healing and cellular crosstalk. This brief review explores these functions and speculates on their role in periodontal disease.
Original languageEnglish
Article number784
Pages (from-to)784
Number of pages6
Issue number7
Publication statusPublished - 22 Jun 2021


  • glycolysis
  • inflammation
  • pyruvate kinase
  • regulation


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