Multidrug efflux pumps: structure, function and regulation

Research output: Contribution to journalReview article

Authors

  • Dijun Du
  • Arthur Neuberger
  • Hendrik W. van Veen
  • Klaas M. Pos
  • Ben F. Luisi

External organisations

  • University of Cambridge
  • Goethe-Universität Frankfurt Am Main

Abstract

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.

Details

Original languageEnglish
Pages (from-to)523-539
Number of pages17
JournalNature Reviews Microbiology
Volume16
Issue number9
Publication statusPublished - 12 Jul 2018

ASJC Scopus subject areas