Multidrug efflux pumps: structure, function and regulation

Dijun Du; Xuan Wang-Kan; Arthur Neuberger; Hendrik W. van Veen; Klaas M. Pos; Laura J.V. Piddock; Ben F. Luisi

doi:10.1038/s41579-018-0048-6

Multidrug efflux pumps: structure, function and regulation

Dijun Du, Xuan Wang-Kan, Arthur Neuberger, Hendrik W. van Veen, Klaas M. Pos, Laura J.V. Piddock, Ben F. Luisi^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

188 Citations (Scopus)

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Abstract

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.

Original language	English
Pages (from-to)	523-539
Number of pages	17
Journal	Nature Reviews Microbiology
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/s41579-018-0048-6
Publication status	Published - 12 Jul 2018

ASJC Scopus subject areas

General Immunology and Microbiology

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Piddock_et_al_Multidrug_efflux_Nature_Reviews_Microbiology_2018
Checked for eligibility 14/09/2018 Dijun Du, Xuan Wang-Kan, Arthur Neuberger, Hendrik W. van Veen, Klaas M. Pos, Laura J. V. Piddock & Ben F. Luisi Multidrug efflux pumps: structure, function and regulation Nature Reviews Microbiologyvolume 16, pages 523–539 (2018) https://doi.org/10.1038/s41579-018-0048-6
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AU - Luisi, Ben F.

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Multidrug efflux pumps: structure, function and regulation

Abstract

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