Multidrug efflux pumps: structure, function and regulation

Dijun Du, Xuan Wang-Kan, Arthur Neuberger, Hendrik W. van Veen, Klaas M. Pos, Laura J.V. Piddock, Ben F. Luisi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

188 Citations (Scopus)
1008 Downloads (Pure)

Abstract

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.

Original languageEnglish
Pages (from-to)523-539
Number of pages17
JournalNature Reviews Microbiology
Volume16
Issue number9
DOIs
Publication statusPublished - 12 Jul 2018

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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