Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin

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Abstract

Exposure of the frog neuromuscular junction to cationized ferritin (200 micrograms ml-1) results in a reduction in MEPP frequency of approximately 25% within 10 min. This effect is not dependent on extracellular Ca2+, and identical results are obtained in salines buffered with EGTA. It is suggested that cationized ferritin does not inhibit transmitter release via a reduction in the intracellular Ca2+ concentration, but exerts its effect by a direct action on exocytosis. A mode of action is proposed. Unlike Con A, cationized ferritin is unable to suppress the stimulation of spontaneous release caused by high osmolarity.

Details

Original languageEnglish
Pages (from-to)246-8
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume318
Issue number3
Publication statusPublished - Feb 1982

Keywords

  • Animals, Concanavalin A, Ferritins, In Vitro Techniques, Ligands, Motor Endplate, Neuromuscular Junction, Neurotransmitter Agents, Osmolar Concentration, Polymers, Rana temporaria