Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin

S J Publicover

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1 Citation (Scopus)


Exposure of the frog neuromuscular junction to cationized ferritin (200 micrograms ml-1) results in a reduction in MEPP frequency of approximately 25% within 10 min. This effect is not dependent on extracellular Ca2+, and identical results are obtained in salines buffered with EGTA. It is suggested that cationized ferritin does not inhibit transmitter release via a reduction in the intracellular Ca2+ concentration, but exerts its effect by a direct action on exocytosis. A mode of action is proposed. Unlike Con A, cationized ferritin is unable to suppress the stimulation of spontaneous release caused by high osmolarity.

Original languageEnglish
Pages (from-to)246-8
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Issue number3
Publication statusPublished - Feb 1982


  • Animals
  • Concanavalin A
  • Ferritins
  • In Vitro Techniques
  • Ligands
  • Motor Endplate
  • Neuromuscular Junction
  • Neurotransmitter Agents
  • Osmolar Concentration
  • Polymers
  • Rana temporaria


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