Imaging of glioma tumor with endogenous fluorescence tomography

Research output: Contribution to journalArticlepeer-review

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Imaging of glioma tumor with endogenous fluorescence tomography. / Kepshire, Dax S; Gibbs-Strauss, Summer L; Gibbs-Struass, Summer L; O'Hara, Julia A; Hutchins, Michael; Mincu, Niculae; Leblond, Frederic; Khayat, Mario; Dehghani, Hamid; Srinivasan, Subhadra; Pogue, Brian W.

In: Journal of Biomedical Optics, Vol. 14, No. 3, 030501, 11.05.2009.

Research output: Contribution to journalArticlepeer-review

Harvard

Kepshire, DS, Gibbs-Strauss, SL, Gibbs-Struass, SL, O'Hara, JA, Hutchins, M, Mincu, N, Leblond, F, Khayat, M, Dehghani, H, Srinivasan, S & Pogue, BW 2009, 'Imaging of glioma tumor with endogenous fluorescence tomography', Journal of Biomedical Optics, vol. 14, no. 3, 030501. https://doi.org/10.1117/1.3127202

APA

Kepshire, D. S., Gibbs-Strauss, S. L., Gibbs-Struass, S. L., O'Hara, J. A., Hutchins, M., Mincu, N., Leblond, F., Khayat, M., Dehghani, H., Srinivasan, S., & Pogue, B. W. (2009). Imaging of glioma tumor with endogenous fluorescence tomography. Journal of Biomedical Optics, 14(3), [030501]. https://doi.org/10.1117/1.3127202

Vancouver

Kepshire DS, Gibbs-Strauss SL, Gibbs-Struass SL, O'Hara JA, Hutchins M, Mincu N et al. Imaging of glioma tumor with endogenous fluorescence tomography. Journal of Biomedical Optics. 2009 May 11;14(3). 030501. https://doi.org/10.1117/1.3127202

Author

Kepshire, Dax S ; Gibbs-Strauss, Summer L ; Gibbs-Struass, Summer L ; O'Hara, Julia A ; Hutchins, Michael ; Mincu, Niculae ; Leblond, Frederic ; Khayat, Mario ; Dehghani, Hamid ; Srinivasan, Subhadra ; Pogue, Brian W. / Imaging of glioma tumor with endogenous fluorescence tomography. In: Journal of Biomedical Optics. 2009 ; Vol. 14, No. 3.

Bibtex

@article{906a738348ae4c66bbd166162e1729b6,
title = "Imaging of glioma tumor with endogenous fluorescence tomography",
abstract = "Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor from within the cranium, even though the tumor presence was not visible in the microCT image. The combination of single-photon counting detection and normalized fluorescence to transmission detection at each channel allowed robust imaging of the signal. This demonstrated use of endogenous fluorescence stimulation from aminolevulinic acid (ALA) and provides the first in vivo demonstration of deep tissue tomographic imaging with protoporphyrin IX.",
keywords = "Aminolevulinic Acid, Animals, Brain Neoplasms, Fluorescence, Glioma, Humans, Photosensitizing Agents, Protoporphyrins, Rats, Transplantation, Heterologous, X-Ray Microtomography",
author = "Kepshire, {Dax S} and Gibbs-Strauss, {Summer L} and Gibbs-Struass, {Summer L} and O'Hara, {Julia A} and Michael Hutchins and Niculae Mincu and Frederic Leblond and Mario Khayat and Hamid Dehghani and Subhadra Srinivasan and Pogue, {Brian W}",
year = "2009",
month = may,
day = "11",
doi = "10.1117/1.3127202",
language = "English",
volume = "14",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "Society of Photo-Optical Instrumentation Engineers",
number = "3",

}

RIS

TY - JOUR

T1 - Imaging of glioma tumor with endogenous fluorescence tomography

AU - Kepshire, Dax S

AU - Gibbs-Strauss, Summer L

AU - Gibbs-Struass, Summer L

AU - O'Hara, Julia A

AU - Hutchins, Michael

AU - Mincu, Niculae

AU - Leblond, Frederic

AU - Khayat, Mario

AU - Dehghani, Hamid

AU - Srinivasan, Subhadra

AU - Pogue, Brian W

PY - 2009/5/11

Y1 - 2009/5/11

N2 - Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor from within the cranium, even though the tumor presence was not visible in the microCT image. The combination of single-photon counting detection and normalized fluorescence to transmission detection at each channel allowed robust imaging of the signal. This demonstrated use of endogenous fluorescence stimulation from aminolevulinic acid (ALA) and provides the first in vivo demonstration of deep tissue tomographic imaging with protoporphyrin IX.

AB - Tomographic imaging of a glioma tumor with endogenous fluorescence is demonstrated using a noncontact single-photon counting fan-beam acquisition system interfaced with microCT imaging. The fluorescence from protoporphyrin IX (PpIX) was found to be detectable, and allowed imaging of the tumor from within the cranium, even though the tumor presence was not visible in the microCT image. The combination of single-photon counting detection and normalized fluorescence to transmission detection at each channel allowed robust imaging of the signal. This demonstrated use of endogenous fluorescence stimulation from aminolevulinic acid (ALA) and provides the first in vivo demonstration of deep tissue tomographic imaging with protoporphyrin IX.

KW - Aminolevulinic Acid

KW - Animals

KW - Brain Neoplasms

KW - Fluorescence

KW - Glioma

KW - Humans

KW - Photosensitizing Agents

KW - Protoporphyrins

KW - Rats

KW - Transplantation, Heterologous

KW - X-Ray Microtomography

U2 - 10.1117/1.3127202

DO - 10.1117/1.3127202

M3 - Article

C2 - 19566285

VL - 14

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 3

M1 - 030501

ER -