How to erase memory traces of pain and fear
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
External organisations
- Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria. juergen.sandkuehler@meduniwien.ac.at
Abstract
Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 343-352 |
| Number of pages | 10 |
| Journal | Trends in Neurosciences |
| Volume | 36 |
| Issue number | 6 |
| Early online date | 18 Apr 2013 |
| Publication status | Published - Jun 2013 |
Keywords
- Analgesics, Opioid, Animals, Anxiety, Conditioning, Classical, Cycloserine, Extinction, Psychological, Fear, Humans, Hyperalgesia, Isoenzymes, Long-Term Potentiation, Memory, Long-Term, Mental Recall, Models, Neurological, Models, Psychological, Nerve Tissue Proteins, Neuroglia, Nociception, Pain, Pain Management, Protein Kinase C, Protein Kinase Inhibitors, Protein Kinases, Rats, Receptors, Ionotropic Glutamate