How to erase memory traces of pain and fear

Jürgen Sandkühler, Jonathan Lee

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)
218 Downloads (Pure)

Abstract

Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies.
Original languageEnglish
Pages (from-to)343-352
Number of pages10
JournalTrends in Neurosciences
Volume36
Issue number6
Early online date18 Apr 2013
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Analgesics, Opioid
  • Animals
  • Anxiety
  • Conditioning, Classical
  • Cycloserine
  • Extinction, Psychological
  • Fear
  • Humans
  • Hyperalgesia
  • Isoenzymes
  • Long-Term Potentiation
  • Memory, Long-Term
  • Mental Recall
  • Models, Neurological
  • Models, Psychological
  • Nerve Tissue Proteins
  • Neuroglia
  • Nociception
  • Pain
  • Pain Management
  • Protein Kinase C
  • Protein Kinase Inhibitors
  • Protein Kinases
  • Rats
  • Receptors, Ionotropic Glutamate

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