GPVI and integrin a11bb3 signaling in platelets

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Colleges, School and Institutes


This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alpha IIb beta 3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase C gamma 2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.


Original languageEnglish
Pages (from-to)1752-1762
Number of pages11
JournalJournal of Thrombosis and Haemostasis
Issue number8
Publication statusPublished - 1 Aug 2005


  • tyrosine kinases, collagen, Syk, Src kinases, GPVL integrin