GPVI and integrin a11bb3 signaling in platelets

Steve Watson; Jocelyn Auger; Owen McCarty; Andrew Pearce

doi:10.1111/j.1538-7836.2005.01429.x

GPVI and integrin a11bb3 signaling in platelets

Steve Watson, Jocelyn Auger, Owen McCarty, Andrew Pearce

Cardiovascular Sciences

Research output: Contribution to journal › Article

303 Citations (Scopus)

Abstract

This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin alpha IIb beta 3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase C gamma 2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.

Original language	English
Pages (from-to)	1752-1762
Number of pages	11
Journal	Journal of Thrombosis and Haemostasis
Volume	3
Issue number	8
DOIs	https://doi.org/10.1111/j.1538-7836.2005.01429.x
Publication status	Published - 1 Aug 2005

Keywords

tyrosine kinases
collagen
Syk
Src kinases
GPVL integrin

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10.1111/j.1538-7836.2005.01429.x

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AU - McCarty, Owen

AU - Pearce, Andrew

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KW - collagen

KW - Syk

KW - Src kinases

KW - GPVL integrin

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GPVI and integrin a11bb3 signaling in platelets

Abstract

Keywords

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