Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers

Research output: Contribution to journalArticle


  • Cristian Samorì
  • Raquel Sainz
  • Chang Guo
  • Francesca Maria Toma
  • Chiara Fabbro
  • Tatiana da Ros
  • Maurizio Prato
  • Kostas Kostarelos
  • Alberto Bianco

Colleges, School and Institutes


Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.


Original languageEnglish
Pages (from-to)1494-6
Number of pages3
JournalChemical Communications
Issue number9
Publication statusPublished - 7 Mar 2010