Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers
Research output: Contribution to journal › Article
Colleges, School and Institutes
Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.
|Number of pages||3|
|Publication status||Published - 7 Mar 2010|