Abstract
Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.
Original language | English |
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Pages (from-to) | 1494-6 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 46 |
Issue number | 9 |
DOIs | |
Publication status | Published - 7 Mar 2010 |