Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers

Cristian Samorì, Hanene Ali-Boucetta, Raquel Sainz, Chang Guo, Francesca Maria Toma, Chiara Fabbro, Tatiana da Ros, Maurizio Prato, Kostas Kostarelos, Alberto Bianco

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)

Abstract

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.
Original languageEnglish
Pages (from-to)1494-6
Number of pages3
JournalChemical Communications
Volume46
Issue number9
DOIs
Publication statusPublished - 7 Mar 2010

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