Determining the parameters governing the electrochemical stability of thiols and disulfides self-assembled monolayer on gold electrodes in physiological medium

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Abstract

Herein we study the electrochemical potential-dependent and time-dependent stability of thiols and disulfides as self-assembled monolayers on gold electrodes. The stability of four representative sulfur-containing compounds: 3-mercaptopropionic acid, 2-mercaptoethanol, 1,4-dithiothreitol and dl-thioctic acid, was assessed in simulated physiological conditions (i.e. phosphate buffer saline). The stability of these molecules was evaluated using cyclic voltammetry and step-potential chronoamperometry. Coordination of the thiols and disulfides significantly affects the stability of the self-assembled monolayer. In addition, studies performed using gold single crystal (100) and (111) electrodes show the superior binding strength of the SAM on the Au(100) surface structure.

Details

Original languageEnglish
JournalJournal of Electroanalytical Chemistry
Early online date20 Jul 2017
Publication statusE-pub ahead of print - 20 Jul 2017

Keywords

  • Self-assembly monolayer of thiols, disulfides , electrochemistry , desorption , surface structure