D-cycloserine potentiates the reconsolidation of cocaine-associated memories

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Colleges, School and Institutes


Conditioned cue-induced relapse to drug seeking is a major challenge to the treatment of drug addiction. It has been proposed that D-cycloserine might be useful in the prevention of relapse by reducing the conditioned reinforcing properties of drug-associated stimuli through facilitation of extinction. Here we show that intrabasolateral amygdala infusions of D-cycloserine in fact potentiate the reconsolidation of stimulus-cocaine memories to increase cue-induced relapse to drug seeking in rats with an extensive drug self-administration history. This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268.


Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalLearning & memory
Issue number1
Publication statusPublished - 1 Jan 2009