Abstract
Conditioned cue-induced relapse to drug seeking is a major challenge to the treatment of drug addiction. It has been proposed that D-cycloserine might be useful in the prevention of relapse by reducing the conditioned reinforcing properties of drug-associated stimuli through facilitation of extinction. Here we show that intrabasolateral amygdala infusions of D-cycloserine in fact potentiate the reconsolidation of stimulus-cocaine memories to increase cue-induced relapse to drug seeking in rats with an extensive drug self-administration history. This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268.
Original language | English |
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Pages (from-to) | 82-85 |
Number of pages | 4 |
Journal | Learning & memory |
Volume | 16 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2009 |