Changes in human hepatic metabolism in steatosis and cirrhosis

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Changes in human hepatic metabolism in steatosis and cirrhosis. / Schofield, Zoe; Reed, Michelle A.C.; Newsome, Philip; Adams, David; Gunther, Ulrich; Lalor, Patricia.

In: World Journal of Gastroenterology, Vol. 23, No. 15, 21.04.2017, p. 2685-2695.

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@article{4b4602fc052e42b7bc2d1d0402232592,
title = "Changes in human hepatic metabolism in steatosis and cirrhosis",
abstract = "AIM: To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver tissue.METHODS: We have carried out pilot study using (1)H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis (NASH) or alcohol-related liver damage (ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries.RESULTS: Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION: Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance.",
keywords = "Journal Article",
author = "Zoe Schofield and Reed, {Michelle A.C.} and Philip Newsome and David Adams and Ulrich Gunther and Patricia Lalor",
year = "2017",
month = apr,
day = "21",
doi = "10.3748/wjg.v23.i15.2685",
language = "English",
volume = "23",
pages = "2685--2695",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "15",

}

RIS

TY - JOUR

T1 - Changes in human hepatic metabolism in steatosis and cirrhosis

AU - Schofield, Zoe

AU - Reed, Michelle A.C.

AU - Newsome, Philip

AU - Adams, David

AU - Gunther, Ulrich

AU - Lalor, Patricia

PY - 2017/4/21

Y1 - 2017/4/21

N2 - AIM: To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver tissue.METHODS: We have carried out pilot study using (1)H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis (NASH) or alcohol-related liver damage (ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries.RESULTS: Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION: Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance.

AB - AIM: To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver tissue.METHODS: We have carried out pilot study using (1)H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis (NASH) or alcohol-related liver damage (ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries.RESULTS: Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION: Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance.

KW - Journal Article

U2 - 10.3748/wjg.v23.i15.2685

DO - 10.3748/wjg.v23.i15.2685

M3 - Article

C2 - 28487605

VL - 23

SP - 2685

EP - 2695

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 15

ER -