CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma

D Scheel-Toellner; E Richter; K M Toellner; N Reiling; H H Wacker; H D Flad; J Gerdes

CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma

D Scheel-Toellner, E Richter, K M Toellner, N Reiling, H H Wacker, H D Flad, J Gerdes

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Leprosy represents a spectrum of clinical manifestations that reflect the immune response to antigens of Mycobacterium leprae. The tuberculoid form of leprosy, which is characterized by an organized development of granulomas, has recently been correlated with a Th1-like immune response. The lepromatous form of leprosy, with a characteristic lack of cellular immunity, has been correlated with a Th2-like immune response to mycobacterial antigens. Dipeptidylpeptidase IV (CD26) is an ectopeptidase that is expressed in various tissues; in the hemopoietic system, it is predominantly expressed by T cells.

Original language	English
Pages (from-to)	685-90
Number of pages	6
Journal	Laboratory investigation
Volume	73
Issue number	5
Publication status	Published - Nov 1995

Keywords

Interferon-gamma
Skin
Humans
Leprosy, Tuberculoid
Sarcoidosis
Fluorescent Antibody Technique, Direct
Lymphadenitis
Leprosy, Lepromatous
Dipeptidyl Peptidase 4
T-Lymphocytes, Helper-Inducer
Immunohistochemistry
Immunoenzyme Techniques
T-Lymphocytes

Cite this

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title = "CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma",

abstract = "Leprosy represents a spectrum of clinical manifestations that reflect the immune response to antigens of Mycobacterium leprae. The tuberculoid form of leprosy, which is characterized by an organized development of granulomas, has recently been correlated with a Th1-like immune response. The lepromatous form of leprosy, with a characteristic lack of cellular immunity, has been correlated with a Th2-like immune response to mycobacterial antigens. Dipeptidylpeptidase IV (CD26) is an ectopeptidase that is expressed in various tissues; in the hemopoietic system, it is predominantly expressed by T cells.",

keywords = "Interferon-gamma, Skin, Humans, Leprosy, Tuberculoid, Sarcoidosis, Fluorescent Antibody Technique, Direct, Lymphadenitis, Leprosy, Lepromatous, Dipeptidyl Peptidase 4, T-Lymphocytes, Helper-Inducer, Immunohistochemistry, Immunoenzyme Techniques, T-Lymphocytes",

author = "D Scheel-Toellner and E Richter and Toellner, {K M} and N Reiling and Wacker, {H H} and Flad, {H D} and J Gerdes",

year = "1995",

month = nov,

language = "English",

volume = "73",

pages = "685--90",

journal = "Laboratory investigation",

issn = "0023-6837",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma

AU - Scheel-Toellner, D

AU - Richter, E

AU - Toellner, K M

AU - Reiling, N

AU - Wacker, H H

AU - Flad, H D

AU - Gerdes, J

PY - 1995/11

Y1 - 1995/11

N2 - Leprosy represents a spectrum of clinical manifestations that reflect the immune response to antigens of Mycobacterium leprae. The tuberculoid form of leprosy, which is characterized by an organized development of granulomas, has recently been correlated with a Th1-like immune response. The lepromatous form of leprosy, with a characteristic lack of cellular immunity, has been correlated with a Th2-like immune response to mycobacterial antigens. Dipeptidylpeptidase IV (CD26) is an ectopeptidase that is expressed in various tissues; in the hemopoietic system, it is predominantly expressed by T cells.

AB - Leprosy represents a spectrum of clinical manifestations that reflect the immune response to antigens of Mycobacterium leprae. The tuberculoid form of leprosy, which is characterized by an organized development of granulomas, has recently been correlated with a Th1-like immune response. The lepromatous form of leprosy, with a characteristic lack of cellular immunity, has been correlated with a Th2-like immune response to mycobacterial antigens. Dipeptidylpeptidase IV (CD26) is an ectopeptidase that is expressed in various tissues; in the hemopoietic system, it is predominantly expressed by T cells.

KW - Interferon-gamma

KW - Skin

KW - Humans

KW - Leprosy, Tuberculoid

KW - Sarcoidosis

KW - Fluorescent Antibody Technique, Direct

KW - Lymphadenitis

KW - Leprosy, Lepromatous

KW - Dipeptidyl Peptidase 4

KW - T-Lymphocytes, Helper-Inducer

KW - Immunohistochemistry

KW - Immunoenzyme Techniques

KW - T-Lymphocytes

M3 - Article

C2 - 7474942

SN - 0023-6837

VL - 73

SP - 685

EP - 690

JO - Laboratory investigation

JF - Laboratory investigation

IS - 5

ER -

CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma

Abstract

Keywords

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