Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux

Research output: Contribution to journalArticle

Abstract

Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid beta-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake. Rats were cold acclimated to induce cardiac hypertrophy and increase cardiac LPL Lipid uptake and metabolism were altered by feeding a 'Western-style' high fat diet (WSD) or feeding oxfenicine (2 g/L) in the drinking water. Diastolic stiffness (increased volume change/unit pressure change) was induced in hypertrophied hearts for rats fed WSD (P

Details

Original languageEnglish
Pages (from-to)627-636
Number of pages10
JournalBiochimica and Biophysica Acta. Molecular and Cell Biology of Lipids
Volume1821
Issue number4
Publication statusPublished - 1 Apr 2012

Keywords

  • Lipoprotein lipase, Very-low-density lipoprotein, Cardiac hypertrophy, ANGPTL4