Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux

David Hauton; Germaine Caldwell

doi:10.1016/j.bbalip.2011.12.004

Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux

David Hauton, Germaine Caldwell

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid beta-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake. Rats were cold acclimated to induce cardiac hypertrophy and increase cardiac LPL Lipid uptake and metabolism were altered by feeding a 'Western-style' high fat diet (WSD) or feeding oxfenicine (2 g/L) in the drinking water. Diastolic stiffness (increased volume change/unit pressure change) was induced in hypertrophied hearts for rats fed WSD (P

Original language	English
Pages (from-to)	627-636
Number of pages	10
Journal	Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids
Volume	1821
Issue number	4
DOIs	https://doi.org/10.1016/j.bbalip.2011.12.004
Publication status	Published - 1 Apr 2012

Keywords

Lipoprotein lipase
Very-low-density lipoprotein
Cardiac hypertrophy
ANGPTL4

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10.1016/j.bbalip.2011.12.004

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abstract = "Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid beta-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake. Rats were cold acclimated to induce cardiac hypertrophy and increase cardiac LPL Lipid uptake and metabolism were altered by feeding a 'Western-style' high fat diet (WSD) or feeding oxfenicine (2 g/L) in the drinking water. Diastolic stiffness (increased volume change/unit pressure change) was induced in hypertrophied hearts for rats fed WSD (P",

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AU - Hauton, David

AU - Caldwell, Germaine

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N2 - Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid beta-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake. Rats were cold acclimated to induce cardiac hypertrophy and increase cardiac LPL Lipid uptake and metabolism were altered by feeding a 'Western-style' high fat diet (WSD) or feeding oxfenicine (2 g/L) in the drinking water. Diastolic stiffness (increased volume change/unit pressure change) was induced in hypertrophied hearts for rats fed WSD (P

AB - Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid beta-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether uptake mechanisms such as lipoprotein lipase (LPL) can be attenuated to diminish this uptake. Rats were cold acclimated to induce cardiac hypertrophy and increase cardiac LPL Lipid uptake and metabolism were altered by feeding a 'Western-style' high fat diet (WSD) or feeding oxfenicine (2 g/L) in the drinking water. Diastolic stiffness (increased volume change/unit pressure change) was induced in hypertrophied hearts for rats fed WSD (P

KW - Lipoprotein lipase

KW - Very-low-density lipoprotein

KW - Cardiac hypertrophy

KW - ANGPTL4

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DO - 10.1016/j.bbalip.2011.12.004

M3 - Article

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JO - Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids

JF - Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids

IS - 4

ER -

Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux

Abstract

Keywords

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