Border control : anatomical origins of the thymus medulla

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Border control : anatomical origins of the thymus medulla. / Anderson, Graham; Jenkinson, William E.

In: European Journal of Immunology, Vol. 45, No. 8, 08.2015, p. 2203-2207.

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@article{5c51f207672a4f1db9ae97cae60202ea,
title = "Border control : anatomical origins of the thymus medulla",
abstract = "The thymus is an anatomically compartmentalized primary lymphoid organ that fosters the production of self-tolerant T cells. The thymic cortex provides a specialized microenvironment in which cortical thymic epithelial cells (cTECs) support the positive selection and further differentiation of self-MHC-restricted thymocytes. Following their migration into the medulla, positively selected thymocytes are further screened for self-reactivity, which involves both negative selection and Foxp3(+) regulatory T cell generation via interactions with medullary thymic epithelial cells (mTECs). Given the importance of both cortical and medullary microenvironments for T cell development, studies that address the developmental origins of cTECs and mTECs are important in understanding the processes that shape the developing T cell receptor repertoire, and reduce the frequency of self-reactive T cells that initiate autoimmune disease. In this issue of the European Journal of Immunology, Onder et al. [Eur. J. Immunol. 2015. 45: 2218-2231] identified a subset of podoplanin(+) mTECs in mice that reside at the corticomedullary junction (CMJ), show that their development is important to establish self-tolerance, and require the presence of self-reactive T cells. Collectively, their findings highlight the CMJ as a potential repository for precursors of the mTEC lineage, and provide a better understanding of thymus medulla formation.",
keywords = "Animals, Cell Differentiation, Epithelial Cells, Membrane Glycoproteins, NF-kappa B, Signal Transduction, Stem Cells, Thymus Gland",
author = "Graham Anderson and Jenkinson, {William E}",
year = "2015",
month = aug,
doi = "10.1002/eji.201545829",
language = "English",
volume = "45",
pages = "2203--2207",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "8",

}

RIS

TY - JOUR

T1 - Border control : anatomical origins of the thymus medulla

AU - Anderson, Graham

AU - Jenkinson, William E

PY - 2015/8

Y1 - 2015/8

N2 - The thymus is an anatomically compartmentalized primary lymphoid organ that fosters the production of self-tolerant T cells. The thymic cortex provides a specialized microenvironment in which cortical thymic epithelial cells (cTECs) support the positive selection and further differentiation of self-MHC-restricted thymocytes. Following their migration into the medulla, positively selected thymocytes are further screened for self-reactivity, which involves both negative selection and Foxp3(+) regulatory T cell generation via interactions with medullary thymic epithelial cells (mTECs). Given the importance of both cortical and medullary microenvironments for T cell development, studies that address the developmental origins of cTECs and mTECs are important in understanding the processes that shape the developing T cell receptor repertoire, and reduce the frequency of self-reactive T cells that initiate autoimmune disease. In this issue of the European Journal of Immunology, Onder et al. [Eur. J. Immunol. 2015. 45: 2218-2231] identified a subset of podoplanin(+) mTECs in mice that reside at the corticomedullary junction (CMJ), show that their development is important to establish self-tolerance, and require the presence of self-reactive T cells. Collectively, their findings highlight the CMJ as a potential repository for precursors of the mTEC lineage, and provide a better understanding of thymus medulla formation.

AB - The thymus is an anatomically compartmentalized primary lymphoid organ that fosters the production of self-tolerant T cells. The thymic cortex provides a specialized microenvironment in which cortical thymic epithelial cells (cTECs) support the positive selection and further differentiation of self-MHC-restricted thymocytes. Following their migration into the medulla, positively selected thymocytes are further screened for self-reactivity, which involves both negative selection and Foxp3(+) regulatory T cell generation via interactions with medullary thymic epithelial cells (mTECs). Given the importance of both cortical and medullary microenvironments for T cell development, studies that address the developmental origins of cTECs and mTECs are important in understanding the processes that shape the developing T cell receptor repertoire, and reduce the frequency of self-reactive T cells that initiate autoimmune disease. In this issue of the European Journal of Immunology, Onder et al. [Eur. J. Immunol. 2015. 45: 2218-2231] identified a subset of podoplanin(+) mTECs in mice that reside at the corticomedullary junction (CMJ), show that their development is important to establish self-tolerance, and require the presence of self-reactive T cells. Collectively, their findings highlight the CMJ as a potential repository for precursors of the mTEC lineage, and provide a better understanding of thymus medulla formation.

KW - Animals

KW - Cell Differentiation

KW - Epithelial Cells

KW - Membrane Glycoproteins

KW - NF-kappa B

KW - Signal Transduction

KW - Stem Cells

KW - Thymus Gland

U2 - 10.1002/eji.201545829

DO - 10.1002/eji.201545829

M3 - Article

C2 - 26109077

VL - 45

SP - 2203

EP - 2207

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 8

ER -