Border control : anatomical origins of the thymus medulla

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Abstract

The thymus is an anatomically compartmentalized primary lymphoid organ that fosters the production of self-tolerant T cells. The thymic cortex provides a specialized microenvironment in which cortical thymic epithelial cells (cTECs) support the positive selection and further differentiation of self-MHC-restricted thymocytes. Following their migration into the medulla, positively selected thymocytes are further screened for self-reactivity, which involves both negative selection and Foxp3(+) regulatory T cell generation via interactions with medullary thymic epithelial cells (mTECs). Given the importance of both cortical and medullary microenvironments for T cell development, studies that address the developmental origins of cTECs and mTECs are important in understanding the processes that shape the developing T cell receptor repertoire, and reduce the frequency of self-reactive T cells that initiate autoimmune disease. In this issue of the European Journal of Immunology, Onder et al. [Eur. J. Immunol. 2015. 45: 2218-2231] identified a subset of podoplanin(+) mTECs in mice that reside at the corticomedullary junction (CMJ), show that their development is important to establish self-tolerance, and require the presence of self-reactive T cells. Collectively, their findings highlight the CMJ as a potential repository for precursors of the mTEC lineage, and provide a better understanding of thymus medulla formation.

Original languageEnglish
Pages (from-to)2203-2207
Number of pages5
JournalEuropean Journal of Immunology
Volume45
Issue number8
Early online date7 Aug 2015
DOIs
Publication statusPublished - Aug 2015

Keywords

  • Animals
  • Cell Differentiation
  • Epithelial Cells
  • Membrane Glycoproteins
  • NF-kappa B
  • Signal Transduction
  • Stem Cells
  • Thymus Gland

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