Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

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Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. / Ge, Haobo; Riss, Patrick J.; Mirabello, Vincenzo; Calatayud, David G.; Flower, Stephen E.; Arrowsmith, Rory L.; Fryer, Tim D.; Hong, Young; Sawiak, Steve; Jacobs, Robert M.J.; Botchway, Stanley W.; Tyrrell, Rex M.; James, Tony D.; Fossey, John S.; Dilworth, Jonathan R.; Aigbirhio, Franklin I.; Pascu, Sofia I.

In: Chem, Vol. 3, No. 3, 14.09.2017, p. 437-460.

Research output: Contribution to journalArticlepeer-review

Harvard

Ge, H, Riss, PJ, Mirabello, V, Calatayud, DG, Flower, SE, Arrowsmith, RL, Fryer, TD, Hong, Y, Sawiak, S, Jacobs, RMJ, Botchway, SW, Tyrrell, RM, James, TD, Fossey, JS, Dilworth, JR, Aigbirhio, FI & Pascu, SI 2017, 'Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo', Chem, vol. 3, no. 3, pp. 437-460. https://doi.org/10.1016/j.chempr.2017.06.013

APA

Ge, H., Riss, P. J., Mirabello, V., Calatayud, D. G., Flower, S. E., Arrowsmith, R. L., Fryer, T. D., Hong, Y., Sawiak, S., Jacobs, R. M. J., Botchway, S. W., Tyrrell, R. M., James, T. D., Fossey, J. S., Dilworth, J. R., Aigbirhio, F. I., & Pascu, S. I. (2017). Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. Chem, 3(3), 437-460. https://doi.org/10.1016/j.chempr.2017.06.013

Vancouver

Author

Ge, Haobo ; Riss, Patrick J. ; Mirabello, Vincenzo ; Calatayud, David G. ; Flower, Stephen E. ; Arrowsmith, Rory L. ; Fryer, Tim D. ; Hong, Young ; Sawiak, Steve ; Jacobs, Robert M.J. ; Botchway, Stanley W. ; Tyrrell, Rex M. ; James, Tony D. ; Fossey, John S. ; Dilworth, Jonathan R. ; Aigbirhio, Franklin I. ; Pascu, Sofia I. / Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo. In: Chem. 2017 ; Vol. 3, No. 3. pp. 437-460.

Bibtex

@article{0d2679e4739740ab906783ec82efb3f6,
title = "Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo",
abstract = "Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).",
keywords = "carbon nanotubes, copper-64, directed and self-assembly, fluorescence microscopy, nano-radiochemistry, nanohybrid materials, positron emission tomography, supramolecular chemistry",
author = "Haobo Ge and Riss, {Patrick J.} and Vincenzo Mirabello and Calatayud, {David G.} and Flower, {Stephen E.} and Arrowsmith, {Rory L.} and Fryer, {Tim D.} and Young Hong and Steve Sawiak and Jacobs, {Robert M.J.} and Botchway, {Stanley W.} and Tyrrell, {Rex M.} and James, {Tony D.} and Fossey, {John S.} and Dilworth, {Jonathan R.} and Aigbirhio, {Franklin I.} and Pascu, {Sofia I.}",
year = "2017",
month = sep,
day = "14",
doi = "10.1016/j.chempr.2017.06.013",
language = "English",
volume = "3",
pages = "437--460",
journal = "Chem",
issn = "2451-9294",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

AU - Ge, Haobo

AU - Riss, Patrick J.

AU - Mirabello, Vincenzo

AU - Calatayud, David G.

AU - Flower, Stephen E.

AU - Arrowsmith, Rory L.

AU - Fryer, Tim D.

AU - Hong, Young

AU - Sawiak, Steve

AU - Jacobs, Robert M.J.

AU - Botchway, Stanley W.

AU - Tyrrell, Rex M.

AU - James, Tony D.

AU - Fossey, John S.

AU - Dilworth, Jonathan R.

AU - Aigbirhio, Franklin I.

AU - Pascu, Sofia I.

PY - 2017/9/14

Y1 - 2017/9/14

N2 - Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).

AB - Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).

KW - carbon nanotubes

KW - copper-64

KW - directed and self-assembly

KW - fluorescence microscopy

KW - nano-radiochemistry

KW - nanohybrid materials

KW - positron emission tomography

KW - supramolecular chemistry

UR - http://www.scopus.com/inward/record.url?scp=85029488808&partnerID=8YFLogxK

U2 - 10.1016/j.chempr.2017.06.013

DO - 10.1016/j.chempr.2017.06.013

M3 - Article

AN - SCOPUS:85029488808

VL - 3

SP - 437

EP - 460

JO - Chem

JF - Chem

SN - 2451-9294

IS - 3

ER -