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Abstract
Hybrid materials based on supramolecularly assembled single-walled carbon nanotubes (SWNTs) are generated for positron emission tomography (PET), magnetic resonance imaging, and fluorescence imaging. The all-in-one imaging probe allows quantitative imaging from subcellular resolution to whole tissue regions. The SWNTs can be exposed to aqueous solutions of non-radioactive and radioactive metal salts in the presence of fullerenes and β-D-glucan. Encapsulating 64Cu ions achieves a minimum of 69% incorporation of radiochemical. The results suggest that this method can be extended to other metal ions of medical relevance, such as zirconium(IV)-89 or rhenium(VII)-188, which are used for medical imaging or radiotherapy, respectively. The in vivo uptake of 64Cu(II)@SWNT@β-D-glucan in Wistar rats allows the investigation of organ biodistribution by microPET. Radioactivity rapidly accumulates predominantly in the lungs and myocardium with peak uptakes of 4.8 ± 0.9 standardized uptake value. Furthermore, such materials are fully traceable in cells by multiphoton fluorescence lifetime imaging with near-infrared excitation (910 nm).
Original language | English |
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Pages (from-to) | 437-460 |
Number of pages | 24 |
Journal | Chem |
Volume | 3 |
Issue number | 3 |
Early online date | 31 Aug 2017 |
DOIs | |
Publication status | Published - 14 Sept 2017 |
Keywords
- carbon nanotubes
- copper-64
- directed and self-assembly
- fluorescence microscopy
- nano-radiochemistry
- nanohybrid materials
- positron emission tomography
- supramolecular chemistry
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- Environmental Chemistry
- General Chemical Engineering
- Biochemistry, medical
- Materials Chemistry
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Dive into the research topics of 'Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo'. Together they form a unique fingerprint.Projects
- 1 Finished
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Boronic Acids for Dye Sensitised Solar Cells
Fossey, J. (Principal Investigator)
Engineering & Physical Science Research Council
23/04/12 → 22/04/14
Project: Research