Asymmetric distribution in twin screw granulation

Research output: Contribution to journalArticlepeer-review

Standard

Asymmetric distribution in twin screw granulation. / Chan Seem, Tim; Rowson, Neil A.; Gabbott, Ian; De Matas, Marcel; Reynolds, Gavin K.; Ingram, Andrew.

In: European Journal of Pharmaceutics and Biopharmaceutics, 25.01.2016.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{59e493b8a0f941fba397ab764ad4d456,
title = "Asymmetric distribution in twin screw granulation",
abstract = "Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill level was determined. High flow asymmetry at low fill level negatively affects granule nucleation leading to high variance in final uniformity. Wetting of material during nucleation was identified as a critical parameter in determining final granule uniformity and fill level is highlighted as a crucial control factor in achieving this. Flow asymmetry of dry material in conveying zones upstream of binder fluid injection leads to poor non-uniform wetting at nucleation and results in heterogeneous final product. The granule formation mechanism of 60 °F kneading blocks is suggested to be primarily breakage of agglomerates formed during nucleation. Optimisation of screw configuration would be required to provide secondary growth. This work shows how fill dependent flow regimes affect granulation mechanisms.",
keywords = "Twin screw granulation, Continuous processes, Pharmaceutical technology, Nucleation, PEPT",
author = "{Chan Seem}, Tim and Rowson, {Neil A.} and Ian Gabbott and {De Matas}, Marcel and Reynolds, {Gavin K.} and Andrew Ingram",
year = "2016",
month = jan,
day = "25",
doi = "10.1016/j.ejpb.2016.01.013",
language = "English",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Asymmetric distribution in twin screw granulation

AU - Chan Seem, Tim

AU - Rowson, Neil A.

AU - Gabbott, Ian

AU - De Matas, Marcel

AU - Reynolds, Gavin K.

AU - Ingram, Andrew

PY - 2016/1/25

Y1 - 2016/1/25

N2 - Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill level was determined. High flow asymmetry at low fill level negatively affects granule nucleation leading to high variance in final uniformity. Wetting of material during nucleation was identified as a critical parameter in determining final granule uniformity and fill level is highlighted as a crucial control factor in achieving this. Flow asymmetry of dry material in conveying zones upstream of binder fluid injection leads to poor non-uniform wetting at nucleation and results in heterogeneous final product. The granule formation mechanism of 60 °F kneading blocks is suggested to be primarily breakage of agglomerates formed during nucleation. Optimisation of screw configuration would be required to provide secondary growth. This work shows how fill dependent flow regimes affect granulation mechanisms.

AB - Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill level was determined. High flow asymmetry at low fill level negatively affects granule nucleation leading to high variance in final uniformity. Wetting of material during nucleation was identified as a critical parameter in determining final granule uniformity and fill level is highlighted as a crucial control factor in achieving this. Flow asymmetry of dry material in conveying zones upstream of binder fluid injection leads to poor non-uniform wetting at nucleation and results in heterogeneous final product. The granule formation mechanism of 60 °F kneading blocks is suggested to be primarily breakage of agglomerates formed during nucleation. Optimisation of screw configuration would be required to provide secondary growth. This work shows how fill dependent flow regimes affect granulation mechanisms.

KW - Twin screw granulation

KW - Continuous processes

KW - Pharmaceutical technology

KW - Nucleation

KW - PEPT

U2 - 10.1016/j.ejpb.2016.01.013

DO - 10.1016/j.ejpb.2016.01.013

M3 - Article

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -