Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers

Research output: Contribution to journalArticle

Authors

  • Nicole A H Janssen
  • Maciej Strak
  • Aileen Yang
  • Bryan Hellack
  • Frank J. Kelly
  • Thomas A J Kuhlbusch
  • Bert Brunekreef
  • Flemming R. Cassee
  • Maaike Steenhof
  • Gerard Hoek

Colleges, School and Institutes

External organisations

  • Institute of Energy and Environmental Technology e.V. (IUTA)
  • King's College London
  • National Institute for Public Health and the Environment (RIVM)
  • King Abdulaziz University
  • University Medical Center Utrecht
  • University College London
  • Environment and Health Administration
  • Institute for Risk Assessment Sciences
  • Department of Internal Medicine, Division of Rheumatology , University of Michigan , Ann Arbor, Michigan , USA ; Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine , University of Michigan , Ann Arbor, Michigan , USA ; Department of Environmental Health Sciences , University of Michigan , Ann Arbor, Michigan , USA.
  • University Duisburg-Essen
  • Department of Land Resources and Environmental Sciences
  • Department of Environmental Sciences / Center of Excellence in Environmental Studies, King Abdulaziz University, PO Box 80203, Jeddah, 21589, Saudi Arabia
  • Utrecht University
  • Public Health Service (GGD) Amsterdam
  • Institute of Energy and Environmental Technology (IUTA)
  • CENIDE
  • MRC-PHE Centre for Environment and Health
  • Julius Center for Health Sciences and Primary Care

Abstract

Introduction We evaluated associations between three a-cellular measures of the oxidative potential (OP) of particulate matter (PM) and acute health effects.

Methods We exposed 31 volunteers for 5 h to ambient air pollution at five locations: an underground train station, two traffic sites, a farm and an urban background site. Each volunteer visited at least three sites. We conducted health measurements before exposure, 2 h after exposure and the next morning. We measured air pollution on site and characterised the OP of PM2.5 and PM10 using three a-cellular assays; dithiotreitol (OPDTT), electron spin resonance (OPESR) and ascorbic acid depletion (OPAA).

Results In single-pollutant models, all measures of OP were significantly associated with increases in fractional exhaled nitric oxide and increases in interleukin-6 in nasal lavage 2 h after exposure. These OP associations remained significant after adjustment for co-pollutants when only the four outdoor sites were included, but lost significance when measurements at the underground site were included. Other health end points including lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP.

Conclusions We found significant associations between three a-cellular measures of OP of PM and markers of airway and nasal inflammation. However, consistency of these effects in two-pollutant models depended on how measurements at the underground site were considered. Lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP. Our study, therefore, provides limited support for a role of OP in predicting acute health effects of PM in healthy young adults.

Details

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalOccupational and Environmental Medicine
Volume72
Issue number1
Publication statusPublished - 1 Jan 2015