Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers

Nicole A H Janssen, Maciej Strak, Aileen Yang, Bryan Hellack, Frank J. Kelly, Thomas A J Kuhlbusch, Roy M. Harrison, Bert Brunekreef, Flemming R. Cassee, Maaike Steenhof, Gerard Hoek

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Introduction We evaluated associations between three a-cellular measures of the oxidative potential (OP) of particulate matter (PM) and acute health effects.

Methods We exposed 31 volunteers for 5 h to ambient air pollution at five locations: an underground train station, two traffic sites, a farm and an urban background site. Each volunteer visited at least three sites. We conducted health measurements before exposure, 2 h after exposure and the next morning. We measured air pollution on site and characterised the OP of PM2.5 and PM10 using three a-cellular assays; dithiotreitol (OPDTT), electron spin resonance (OPESR) and ascorbic acid depletion (OPAA).

Results In single-pollutant models, all measures of OP were significantly associated with increases in fractional exhaled nitric oxide and increases in interleukin-6 in nasal lavage 2 h after exposure. These OP associations remained significant after adjustment for co-pollutants when only the four outdoor sites were included, but lost significance when measurements at the underground site were included. Other health end points including lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP.

Conclusions We found significant associations between three a-cellular measures of OP of PM and markers of airway and nasal inflammation. However, consistency of these effects in two-pollutant models depended on how measurements at the underground site were considered. Lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP. Our study, therefore, provides limited support for a role of OP in predicting acute health effects of PM in healthy young adults.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalOccupational and Environmental Medicine
Volume72
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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