Airflow obstruction and the metabolic syndrome: the Guangzhou Biobank Cohort Study.
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Colleges, School and Institutes
There is some evidence that chronic obstructive pulmonary disease (COPD) and the metabolic syndrome may be related, perhaps through systemic inflammation which is common to both. However, the association between the two conditions has not yet been clearly shown.The present study involved 7,358 adults aged >/=50 years from a population-based survey, who undertook spirometry, a structured interview and had fasting metabolic markers measured.Airflow obstruction (forced expiratory volume in one second/forced vital capacity ratio less than the lower limit of normal) was present in 6.7%, and the International Diabetes Federation metabolic syndrome criteria were met by 20.0%. The risk of metabolic syndrome was higher in those with airflow obstruction compared to those without (OR=1.47, 95% CI 1.12-1.92), after controlling for potential confounders. Of the five components of the metabolic syndrome, only central obesity was significantly associated with airflow obstruction (OR=1.43, 1.09-1.88) after adjusting for body mass index. Similar association was observed in both never and current smokers.In this Chinese sample, airflow obstruction was associated with the metabolic syndrome, and in particular, its central obesity component. This may help explain the increased risk of cardiovascular diseases in COPD and so could guide future clinical practice.
|Journal||The European respiratory journal|
|Publication status||Published - 2 Jul 2009|
- comorbidity, Central obesity, general population, China, chronic obstructive pulmonary disease