A study of soft tissue sarcomas after childhood cancer in Britain

Helen Jenkinson; David Winter; HB Marsden; MA Stovall; MCG Stevens; CA Stiller; Michael Hawkins

doi:10.1038/sj.bjc.6603908

A study of soft tissue sarcomas after childhood cancer in Britain

Helen Jenkinson, David Winter, HB Marsden, MA Stovall, MCG Stevens, CA Stiller, Michael Hawkins

Birmingham Medical School

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Abstract

Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When retinoblastomas were excluded from the cohort, the SIR for STSs was 15.9, and the cumulative risk of developing a soft tissue tumour after childhood cancer within 20 years of 3-year survival was 0.23%. In the case-control study, there was a significant excess of STSs in those patients exposed to both radiotherapy (RT) and chemotherapy, which was five times that observed among those not exposed (P=0.02). On the basis of individual radiation dosimetry, there was evidence of a strong dose-response effect with a significant increase in the risk of STS with increasing dose of RT (P

Original language	English
Pages (from-to)	695-699
Number of pages	5
Journal	British Journal of Cancer
Volume	97
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6603908
Publication status	Published - 24 Jul 2007

Keywords

childhood cancer
second soft tissue sarcoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6603908

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abstract = "Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When retinoblastomas were excluded from the cohort, the SIR for STSs was 15.9, and the cumulative risk of developing a soft tissue tumour after childhood cancer within 20 years of 3-year survival was 0.23%. In the case-control study, there was a significant excess of STSs in those patients exposed to both radiotherapy (RT) and chemotherapy, which was five times that observed among those not exposed (P=0.02). On the basis of individual radiation dosimetry, there was evidence of a strong dose-response effect with a significant increase in the risk of STS with increasing dose of RT (P",

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T1 - A study of soft tissue sarcomas after childhood cancer in Britain

AU - Jenkinson, Helen

AU - Winter, David

AU - Marsden, HB

AU - Stovall, MA

AU - Stevens, MCG

AU - Stiller, CA

AU - Hawkins, Michael

PY - 2007/7/24

Y1 - 2007/7/24

N2 - Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When retinoblastomas were excluded from the cohort, the SIR for STSs was 15.9, and the cumulative risk of developing a soft tissue tumour after childhood cancer within 20 years of 3-year survival was 0.23%. In the case-control study, there was a significant excess of STSs in those patients exposed to both radiotherapy (RT) and chemotherapy, which was five times that observed among those not exposed (P=0.02). On the basis of individual radiation dosimetry, there was evidence of a strong dose-response effect with a significant increase in the risk of STS with increasing dose of RT (P

AB - Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When retinoblastomas were excluded from the cohort, the SIR for STSs was 15.9, and the cumulative risk of developing a soft tissue tumour after childhood cancer within 20 years of 3-year survival was 0.23%. In the case-control study, there was a significant excess of STSs in those patients exposed to both radiotherapy (RT) and chemotherapy, which was five times that observed among those not exposed (P=0.02). On the basis of individual radiation dosimetry, there was evidence of a strong dose-response effect with a significant increase in the risk of STS with increasing dose of RT (P

KW - childhood cancer

KW - second soft tissue sarcoma

U2 - 10.1038/sj.bjc.6603908

DO - 10.1038/sj.bjc.6603908

M3 - Article

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JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 5

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A study of soft tissue sarcomas after childhood cancer in Britain

Abstract

Keywords

UN SDGs

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