A study of soft tissue sarcomas after childhood cancer in Britain

Helen Jenkinson, David Winter, HB Marsden, MA Stovall, MCG Stevens, CA Stiller, Michael Hawkins

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24 Citations (Scopus)


Among 16 541 3-year survivors of childhood cancer in Britain, 39 soft tissue sarcomas (STSs) occurred and 1.1 sarcomas were expected, yielding a standardised incidence ratio (SIR) of 16.1. When retinoblastomas were excluded from the cohort, the SIR for STSs was 15.9, and the cumulative risk of developing a soft tissue tumour after childhood cancer within 20 years of 3-year survival was 0.23%. In the case-control study, there was a significant excess of STSs in those patients exposed to both radiotherapy (RT) and chemotherapy, which was five times that observed among those not exposed (P=0.02). On the basis of individual radiation dosimetry, there was evidence of a strong dose-response effect with a significant increase in the risk of STS with increasing dose of RT (P
Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalBritish Journal of Cancer
Issue number5
Publication statusPublished - 24 Jul 2007


  • childhood cancer
  • second soft tissue sarcoma


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