Adam Croft

ORCID: 0000-0002-9487-0511

Colleges, School and Institutes

Willingness to take PhD students

Yes

PhD projects

Dr Croft's main research interest is in the development of novel immunotherapies for patients with autoimmune rheumatic and chronic inflammatory diseases. He has a particular interest in the development of stromal cell specific targets. His clinical interests include management of both early and treatment resistant inflammatory arthritis. He is also interested in the management of rare systemic inflammatory diseases including vasculitis.

PhD opportunites are available within the Rheumatology Research Group

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Most downloaded publications

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism
Wilhelm, A., Victoria Day, Debs Haldar, Amy Naylor, Christopher Weston, Abhilok Garg, Fear, J., Reynolds, G. M., Adam Croft, Henderson, N. C., Christopher Buckley & Philip Newsome, 15 Jun 2015, In : Gut.

Research output: Contribution to journal › Article

202 downloads
Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis
Bustamante, M. F., Oliveira, P. G., Garcia-Carbonell, R., Adam Croft, Smith, J. M., Serrano, R. L., Sanchez-Lopez, E., Liu, X., Kisseleva, T., Hay, N., Christopher Buckley, Firestein, G. S., Murphy, A. N., Miyamoto, S. & Guma, M., 30 Jul 2018, In : Annals of the Rheumatic Diseases.

Research output: Contribution to journal › Article

139 downloads
11beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis
Rowan Hardy, Fenton, C., Adam Croft, Amy Naylor, Begum, R., Guillaume Desanti, Christopher Buckley, Gareth Lavery, Cooper, M. S. & Karim Raza, 1 Aug 2018, In : Journal of Autoimmunity. 92, p. 104-113 10 p.

Research output: Contribution to journal › Article

129 downloads
Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis
Stuart Smith, Adam Croft, Morris, H. L., Amy Naylor, Huso, D. L., Isacke, C. M., Caroline Savage & Christopher Buckley, 4 Dec 2015, In : Nephron. 131, 4

Research output: Contribution to journal › Article

87 downloads
Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
Adam Croft, Amy Naylor, Jennifer Marshall, Jason Turner, Guillaume Desanti, Adams, H., Adrian Yemm, Andrew Filer & Christopher Buckley, 18 Nov 2016, In : Arthritis Research & Therapy. 18, 270.

Research output: Contribution to journal › Article

76 downloads

Recent publications

Synovial fibroblast positional identity controlled by inductive Notch signaling underlies pathologic damage in inflammatory arthritis
Jennifer Marshall, Major, T., Adam Croft, Andrew Filer, Karim Raza & Christopher Buckley, 5 Dec 2019, (Accepted/In press) In : Nature.

Research output: Contribution to journal › Article

Distinct fibroblast subsets drive inflammation and damage in arthritis
Croft, A. P., Campos, J., Jansen, K., Turner, J. D., Marshall, J., Attar, M., Savary, L., Wehmeyer, C., Naylor, A. J., Kemble, S., Begum, J., Dürholz, K., Perlman, H., Barone, F., McGettrick, H. M., Fearon, D. T., Wei, K., Raychaudhuri, S., Korsunsky, I., Brenner, M. B. & 4 others, Coles, M., Sansom, S. N., Andrew Filer & Christopher Buckley, 29 May 2019, In : Nature. 570, p. 246–251 24 p.

Research output: Contribution to journal › Article

11beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis
Rowan Hardy, Fenton, C., Adam Croft, Amy Naylor, Begum, R., Guillaume Desanti, Christopher Buckley, Gareth Lavery, Cooper, M. S. & Karim Raza, 1 Aug 2018, In : Journal of Autoimmunity. 92, p. 104-113 10 p.

Research output: Contribution to journal › Article

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